The invention discloses a wash-resisting hand cream. The hand cream comprises wool fat, vaseline, mineral oil, hydrogenated polyisobutene, caprylic / capric triglyceride, phytosterol, ceramide 3, polydimethylsiloxane, dimethiconol, C12-15 alcohol benzoate, cetyl phosphate, triethanolamine, hydroxyethyl acrylate / acrylyl dimethyl sodium taurate copolymer, dipropylene glycol, hydroxyethylurea, compound amino acid, glycerol, essence, preservative and deionized water. Cetyl phosphate with high water resistance and a structure similar to that of skin is adopted for the wash-resisting hand cream, a wash-resisting protection film is formed after cetyl phosphate is matched with vaseline and mineral oil which are high in closure property, other nourishing ingredients not prone to migration under washing and various moisturizing and water reserving ingredients are also adopted, and then the functions of highly nourishing, moisturizing, repairing, anti-chapping and hand skin smoothing are realized and the content of the nourishing ingredients can still be high after multiple times of washing.