Artificial bezoar and preparation method thereof

Abstract

The invention discloses an artificial bezoar, which comprises the following components in parts by weight: 5-10 parts of taurine, 15-25 parts of bovine bile powder, 3-6 parts of cholic acid, 3-6 parts of zinc sulfate, bilirubin 3‑6 parts, calcium gluconate 25‑35 parts, hyodeoxycholic acid 25‑35 parts, cholesterol 3‑6 parts, starch 5‑9 parts, etc. The preparation method includes: (1) Weighing and ball milling the substances except starch, amylase, snow pear juice and honeysuckle extract respectively; (2) mixing the starch, snow pear juice and honeysuckle extract according to the formula and placing 2h; (3) Mix the remaining substances except ox gall powder, stir for 40-60min, then add ox gall powder, and stir for 30-40min; (4) Add the result of step (2) to the result of step (3) In, stirring for 20‑30min, prepared. The product can cover glutinous, fishy and bitter tastes, has simple preparation method, low cost and can be industrialized.

Description

technical field

[0001] The invention belongs to the technical field of artificially synthesized drugs, and in particular relates to an artificial bezoar and a preparation method thereof. Background technique

[0002] Bezoar, the dried gallstones of bovid cattle (Bos Taurus domesticus Gmelin). Traditional Chinese medicine believes that bezoar gas is fragrant, slightly bitter and then sweet, and cool in nature. It can be used for antipyretic, detoxification, calming convulsions, taking orally to treat high fever, coma, mania, convulsions in children, convulsions and other diseases. External use controls sore throat, aphtha and carbuncle, and treats toxins. Because natural bezoar is very precious, the international price is higher than that of gold, and now most of the so-called artificial bezoar is used.

[0003] Artificial bezoar is composed of bovine gall powder, cholic acid, hyodeoxycholic acid, taurine, bilirubin, cholesterol and trace elements. Bezoar powder has a fou...

Examples

Embodiment 1

[0023] An artificial calculus comprising the following components in parts by weight: 5 parts of taurine, 15 parts of ox gall powder, 3 parts of cholic acid, 3 parts of zinc sulfate, 3 parts of bilirubin, 25 parts of calcium gluconate, hyodeoxychol 25 parts of acid, 3 parts of cholesterol, 5 parts of starch, 0.1 part of amylase, 1 part of pear juice and 0.5 part of honeysuckle extract.

[0024] Wherein, snowflake pear juice is prepared by the following method: fresh snowflake pears are cleaned, seeded and cored, cut into small pieces, beaten, squeezed and filtered, and filter residues are removed to obtain snowflake pear juice.

[0025] The honeysuckle extract is prepared by the following method: take honeysuckle, dry and crush it to 60 mesh, and then place it in SFE-CO 2 Extractor extraction, extraction temperature is 45°C, extraction pressure is 30MPa, extraction time is 1.5h, CO 2 The flow rate is 20L / h, and the fixed entrainer is absolute ethanol.

[0026] The preparatio...

Embodiment 2

[0032] An artificial calculus comprising the following components in parts by weight: 10 parts of taurine, 25 parts of ox gall powder, 6 parts of cholic acid, 6 parts of zinc sulfate, 6 parts of bilirubin, 35 parts of calcium gluconate, hyodeoxychole 35 parts of acid, 6 parts of cholesterol, 9 parts of starch, 0.3 parts of amylase, 3 parts of pear juice and 1.2 parts of honeysuckle extract.

[0033] Wherein, snowflake pear juice is prepared by the following method: fresh snowflake pears are cleaned, seeded and cored, cut into small pieces, beaten, squeezed and filtered, and filter residues are removed to obtain snowflake pear juice.

[0034] The honeysuckle extract is prepared by the following method: take honeysuckle, dry and crush it to 80 mesh, and then place it in SFE-CO 2 Extractor extraction, extraction temperature is 45°C, extraction pressure is 30MPa, extraction time is 1.5h, CO 2 The flow rate is 20L / h, and the fixed entrainer is absolute ethanol.

[0035] The prepa...

Embodiment 3

[0041] An artificial calculus comprising the following components in parts by weight: 6 parts of taurine, 18 parts of ox gall powder, 4 parts of cholic acid, 4 parts of zinc sulfate, 4 parts of bilirubin, 28 parts of calcium gluconate, hyodeoxychol 28 parts of acid, 4 parts of cholesterol, 6 parts of starch, 0.15 parts of amylase, 1.5 parts of pear juice and 0.8 parts of honeysuckle extract.

[0042] Wherein, snowflake pear juice is prepared by the following method: fresh snowflake pears are cleaned, seeded and cored, cut into small pieces, beaten, squeezed and filtered, and filter residues are removed to obtain snowflake pear juice.

[0043] The honeysuckle extract is prepared by the following method: take honeysuckle, dry and crush it to 60 mesh, and then place it in SFE-CO 2 Extractor extraction, extraction temperature is 45°C, extraction pressure is 30MPa, extraction time is 1.5h, CO 2 The flow rate is 20L / h, and the fixed entrainer is absolute ethanol.

[0044] The prep...

technical field

[0001] The invention belongs to the technical field of artificially synthesized drugs, and in particular relates to an artificial bezoar and a preparation method thereof. Background technique

[0002] Bezoar, the dried gallstones of bovid cattle (Bos Taurus domesticus Gmelin). Traditional Chinese medicine believes that bezoar gas is fragrant, slightly bitter and then sweet, and cool in nature. It can be used for antipyretic, detoxification, calming convulsions, taking orally to treat high fever, coma, mania, convulsions in children, convulsions and other diseases. External use controls sore throat, aphtha and carbuncle, and treats toxins. Because natural bezoar is very precious, the international price is higher than that of gold, and now most of the so-called artificial bezoar is used.

[0003] Artificial bezoar is composed of bovine gall powder, cholic acid, hyodeoxycholic acid, taurine, bilirubin, cholesterol and trace elements. Bezoar powder has a fou...

Examples

Embodiment 1

[0023] An artificial calculus comprising the following components in parts by weight: 5 parts of taurine, 15 parts of ox gall powder, 3 parts of cholic acid, 3 parts of zinc sulfate, 3 parts of bilirubin, 25 parts of calcium gluconate, hyodeoxychol 25 parts of acid, 3 parts of cholesterol, 5 parts of starch, 0.1 part of amylase, 1 part of pear juice and 0.5 part of honeysuckle extract.

[0024] Wherein, snowflake pear juice is prepared by the following method: fresh snowflake pears are cleaned, seeded and cored, cut into small pieces, beaten, squeezed and filtered, and filter residues are removed to obtain snowflake pear juice.

[0025] The honeysuckle extract is prepared by the following method: take honeysuckle, dry and crush it to 60 mesh, and then place it in SFE-CO 2 Extractor extraction, extraction temperature is 45°C, extraction pressure is 30MPa, extraction time is 1.5h, CO 2 The flow rate is 20L / h, and the fixed entrainer is absolute ethanol.

[0026] The preparatio...

Embodiment 2

[0032] An artificial calculus comprising the following components in parts by weight: 10 parts of taurine, 25 parts of ox gall powder, 6 parts of cholic acid, 6 parts of zinc sulfate, 6 parts of bilirubin, 35 parts of calcium gluconate, hyodeoxychole 35 parts of acid, 6 parts of cholesterol, 9 parts of starch, 0.3 parts of amylase, 3 parts of pear juice and 1.2 parts of honeysuckle extract.

[0033] Wherein, snowflake pear juice is prepared by the following method: fresh snowflake pears are cleaned, seeded and cored, cut into small pieces, beaten, squeezed and filtered, and filter residues are removed to obtain snowflake pear juice.

[0034] The honeysuckle extract is prepared by the following method: take honeysuckle, dry and crush it to 80 mesh, and then place it in SFE-CO 2 Extractor extraction, extraction temperature is 45°C, extraction pressure is 30MPa, extraction time is 1.5h, CO 2 The flow rate is 20L / h, and the fixed entrainer is absolute ethanol.

[0035] The prepa...

Embodiment 3

[0041] An artificial calculus comprising the following components in parts by weight: 6 parts of taurine, 18 parts of ox gall powder, 4 parts of cholic acid, 4 parts of zinc sulfate, 4 parts of bilirubin, 28 parts of calcium gluconate, hyodeoxychol 28 parts of acid, 4 parts of cholesterol, 6 parts of starch, 0.15 parts of amylase, 1.5 parts of pear juice and 0.8 parts of honeysuckle extract.

[0042] Wherein, snowflake pear juice is prepared by the following method: fresh snowflake pears are cleaned, seeded and cored, cut into small pieces, beaten, squeezed and filtered, and filter residues are removed to obtain snowflake pear juice.

[0043] The honeysuckle extract is prepared by the following method: take honeysuckle, dry and crush it to 60 mesh, and then place it in SFE-CO 2 Extractor extraction, extraction temperature is 45°C, extraction pressure is 30MPa, extraction time is 1.5h, CO 2 The flow rate is 20L / h, and the fixed entrainer is absolute ethanol.

[0044] The prep...