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Chinese medicinal preparation for freating coronary heart disease, brain arteriosclerosis and its preparation method

A technology for cerebral arteriosclerosis and traditional Chinese medicine preparations, which is applied in the field of traditional Chinese medicine preparations and their preparation, can solve the problems of narrow applicable population, drug bioavailability, unsatisfactory drug stability, insufficient variety of dosage forms, etc., so as to shorten the onset time. , high bioavailability, absorption rate and bioavailability improvement effect

Active Publication Date: 2008-07-09
GUIZHOU JINGCHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the continuing research, it is found that due to the defects of the drug extraction process, the bioavailability and drug stability of the drug are not ideal, and the variety of dosage forms is not rich enough, and the scope of the applicable population is narrow

Method used

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  • Chinese medicinal preparation for freating coronary heart disease, brain arteriosclerosis and its preparation method
  • Chinese medicinal preparation for freating coronary heart disease, brain arteriosclerosis and its preparation method
  • Chinese medicinal preparation for freating coronary heart disease, brain arteriosclerosis and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Embodiment 1 of the present invention: make dropping pill

[0068] Use 400g of Ginkgo biloba leaves, 400g of Buxus microphylla, 400g of Salvia miltiorrhiza, 400g of Zingiber officinalis, and 400g of Allium scallops to prepare according to the following process:

[0069] (1) Take Ginkgo biloba leaves, pulverize them, heat and reflux with dilute ethanol to extract three times, combine the extracts, recover the ethanol and concentrate it to an appropriate amount, add it to the treated macroporous adsorption resin column, and then add 5% to 70% ethanol solution For elution, collect the corresponding eluate, recover ethanol, and spray dry to obtain. Compared with the extract of Xinnaoning Capsules, the extract of this process has higher active ingredient content, less impurities and controllable quality.

[0070] (2) Take Danshen, pulverize it, and use supercritical CO 2 extraction. 5L Supercritical CO 2 The extraction device (HA-9508) is separated by two analytical tank...

Embodiment 2

[0075] Embodiment 2 of the present invention: prepare tablet

[0076] Use 400g of Ginkgo biloba leaves, 400g of Buxus microphylla, 400g of Salvia miltiorrhiza, 400g of Zingiber officinalis, and 400g of Allium scallops to prepare according to the following process:

[0077] (1) Take Ginkgo biloba leaves, pulverize them, heat and reflux with dilute ethanol to extract three times, combine the extracts, recover the ethanol and concentrate it to an appropriate amount, add it to the treated macroporous adsorption resin column, and then add 5% to 70% ethanol solution For elution, collect the corresponding eluate, recover ethanol, and spray dry to obtain. Compared with the extract of Xinnaoning Capsules, the extract of this process has higher active ingredient content, less impurities and controllable quality.

[0078] (2) Take Danshen, pulverize it, and use supercritical CO 2 extraction. 5L Supercritical CO 2 The extraction device (HA-9508) is separated by two analytical tanks an...

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Abstract

A Chinese medicine for treating coronary heart disease and cerebral arteriosclerosis is prepared from 5 Chinese-medicinal materials including ginkgo leaf, red sage root, longstamen onion bulb, etc through supercritial extracting and macroreticular resin purifying. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine preparation for treating coronary heart disease and cerebral arteriosclerosis and a preparation method thereof. Background technique [0002] Coronary heart disease and cerebral arteriosclerosis are common diseases, which seriously affect people's health. And existing treatment coronary heart disease, cerebral arteriosclerosis medicine is also a lot, but most curative effects are not quite satisfactory. In order to achieve the purpose of treatment, many inventors and pharmaceutical companies have done a lot of research, and also provided some treatment products; such as ZL02127973. Development, after a long-term clinical application to prove the definite curative effect. However, in the continuing research, it is found that due to the defects of the drug extraction process, the bioavailability and drug ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8962A61K36/54A61K36/53A61K36/185A61K36/16A61K9/20A61P9/10
Inventor 徐和
Owner GUIZHOU JINGCHENG PHARMA
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