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Application of Rangoon creeper fruit and its extracts in preparation of medicine for promoting lead expelling

A technology of traditional Chinese medicine preparation and extract, which is applied in the field of application of Chinese medicine making gentleman

Inactive Publication Date: 2009-08-12
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether Shijunzi has the effect of promoting lead excretion in human body has not been reported in the literature

Method used

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  • Application of Rangoon creeper fruit and its extracts in preparation of medicine for promoting lead expelling
  • Application of Rangoon creeper fruit and its extracts in preparation of medicine for promoting lead expelling

Examples

Experimental program
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Effect test

Embodiment 1

[0013] Experimental animals: 50 healthy Kunming mice, clean grade, half male and half female, body weight 20±2 grams, divided into 5 groups, namely blank control group, lead-stained model group, high, medium and low decoction 3 dose groups, 10 rats in each group. Lead acetate was dissolved in distilled water and injected intraperitoneally at 40 mg / kg to establish a lead-exposed animal model in mice.

[0014] The decoction of the gentleman is prepared by a conventional decoction method, and concentrated to a corresponding concentration. The different dosage groups of the decoction include a high-dose group (12g / kg), a middle-dose group (9g / kg), a low-dose group (6g / kg ), each group was given intragastrically, and the other groups were given the same amount of normal saline, and the experiment continued for 4 weeks. After the administration, take 40ul of blood from the right femoral vein of the mouse, put it into a covered plastic centrifuge tube filled with 0.36ml of 1% nitric...

Embodiment 2

[0020] Experimental animals: 50 healthy Kunming mice, clean grade, half male and half female, body weight 20±2 grams, divided into 5 groups, namely blank control group, lead-stained model group, high, medium and low decoction 3 dose groups, 10 rats in each group. Lead acetate was dissolved in distilled water and injected intraperitoneally at 40 mg / kg to establish a lead-exposed animal model in mice.

[0021] Take Smilax Smilax and Smilax Smilax by the same weight ratio, adopt conventional decoction method to prepare Smilax Smilax Smilax decoction, and be concentrated into corresponding concentration, each medication group is administered by intragastric administration, and different dosage groups include high-dose group (12g / kg), the middle dose group (9g / kg), and the low dose group (6g / kg) were given intragastrically respectively, and all the other groups were given an equivalent amount of normal saline, and the experiment was administered continuously for 4 weeks. After th...

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Abstract

The invention discloses the novel use of rangooncreeper fruit or its extract in preparing Chinese medicinal preparation having actions of lead discharge acceleration, the preparation has less toxic and side effects,and can be prepared into medicaments or health products.

Description

technical field [0001] The invention relates to the application of the traditional Chinese medicine Shijunzi, in particular to the application of Shijunzi or its extracts in the preparation of traditional Chinese medicine preparations for promoting the role of lead excretion in the body. technical background [0002] Lead is an important industrial poison and environmental pollutant. It exists widely in the environment and is difficult to degrade. It can enter the human body through food, water, soil and air. After entering the human body, lead is excreted very slowly. The biological half-life of bone lead is about 20 years, and the biological half-life of lead in cortical bone is longer. Although the environmental lead concentration is below the allowable value, in recent years, with the increase of automobiles and motorcycles, the lead content in the atmosphere has become higher and higher. At the same time, the use of a large number of chemical products has also increased...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61K36/258A61K36/9062A61K35/62A61K36/896A61K36/53A61K35/56A61K36/37A61K36/236A61P39/02A61K35/618
Inventor 余绍蕾蔡宇
Owner JINAN UNIVERSITY
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