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Ibuprofen rapidly disintegrating tablet in oral cavity for pain treatment and preparing method thereof

A technology for oral disintegrating tablets and disintegrating agents, applied in the field of medicine, can solve the problems of negative impact of disintegration, unqualified disintegration of ibuprofen orally disintegrating tablets, and inability to effectively improve taste of ibuprofen orally disintegrating tablets. , to achieve the effect of improving taste, improving taste and appearance, and ensuring disintegration speed

Inactive Publication Date: 2007-09-12
南京亿华药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to cover up the spicy taste of raw materials, a large amount of correctives are usually used, but this method not only cannot effectively improve the taste of ibuprofen orally disintegrating tablets, but also has a negative impact on disintegration, resulting in the disintegration of ibuprofen orally disintegrating tablets unqualified

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0025] Implementation 1 example:

[0026] Ibuprofen 100g

[0027] Glyceryl Palmitostearate 10g

[0028] Microcrystalline Cellulose 60g

[0029] Lactose 90g

[0030] Crospovidone 30g

[0031] NaHCO 3 20g

[0032] Mannitol 30g

[0033] Citric acid 20g

[0034] Aspartame 10g

[0035] Starch 15g

[0036] Flavor 0.6g

[0037] Lake 0.5g

[0038] Made into 1000 pieces

[0039] Preparation process: mix the main ingredient and glyceryl palmitostearate at room temperature for 2-5 minutes, heat up and melt in a container of suitable size, the temperature is slightly higher than the melting point of the molten base (57-60°C), use available Stir with a speed-regulating agitator while slowly cooling to room temperature to obtain fine particles of the main drug. The excipients in the prescription were crushed through a 100-mesh sieve, weighed the excipients in the prescribed amount, mixed with the main drug granules, and the m...

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PUM

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Abstract

The orally disintegrated ibuprofen tablet consists of ibuprofen; glyceryl palmitate-stearate in the amount of 5-20 wt% of ibuprofen; excipient of mannitol, microcrystalline cellulose and / or lactose; and disintegrant of cross-linked polyvidone or carboxymethyl starch sodium as conventional disintegrant, and supplementary material NaHCO3 and citric acid to form effervescent disintegrant with high disintegrating speed and good taste. The orally disintegrated ibuprofen tablet may have aspartame, edible essence and edible color lake added to improve taste and look. The present invention also discloses its preparation process.

Description

Technical field: [0001] The invention relates to medicines, in particular to ibuprofen orally disintegrating tablets for treating colds and pains and a preparation method thereof. Background technique: [0002] Ibuprofen is a phenylpropionic acid non-steroidal anti-inflammatory drug with strong anti-inflammatory, analgesic and antipyretic effects. In the foreign pharmaceutical market, ibuprofen has been showing a steady growth trend. Together with paracetamol, aspirin and diclofenac, it has become the four pillar products in the antipyretic and analgesic drug market in my country. However, ibuprofen has its own characteristics in clinical application. It is also a safe and effective antipyretic drug. When the body temperature is higher than 39.2°C, ibuprofen is more effective than paracetamol at the same dose, and the antipyretic time is longer. Pharmacodynamic studies have proved that the analgesic and antipyretic effects of this drug are 28 times and 20 times that of aspi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/192A61K47/14A61K47/10A61K47/38A61K47/34A61K47/36A61K9/46A61K47/02A61P29/00A61K47/32
Inventor 杨鹏辉
Owner 南京亿华药业有限公司
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