Mangiferin-berberine composition

A technology of berberine and mangiferin, which is applied in the field of mangiferin-berberine compositions, can solve the problems of poor water solubility of berberine salts and difficulty in preparation selection, and achieve good water solubility

Inactive Publication Date: 2007-11-07
广西中医学院
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  • Summary
  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

Due to the poor water solubility of berberine salts, it

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0019] Weigh 26.5 grams of mangiferin and 23.5 grams of berberine hydrochloride, put them in a container, add 6000ml of 35% ethanol aqueous solution, stir while heating, and dissolve completely after slightly heating up; reclaim ethanol under reduced pressure, further concentrate to 2000ml, filter , to obtain a mangiferin-berberine composition solution with a concentration of 2.5%. This solution is very stable.

preparation example 2

[0021] Weigh 28 grams of mangiferin and 22 grams of berberine, put them in a container, add 3000ml of 25% ethanol aqueous solution, stir while heating, until they are completely dissolved; recover the ethanol under reduced pressure, further concentrate to 500ml, and filter to obtain mango Glycoside-berberine composition solution, concentration 10%. After preparation, it should be used in the next process within 3 hours to avoid crystallization.

preparation example 3

[0023] Weigh 26.2 grams of mangiferin and 23.8 grams of berberine sulfate, put them in a container, add 5000ml of 20% ethanol aqueous solution, stir while heating, until they are completely dissolved; recover ethanol under reduced pressure, further concentrate to 1250ml, and filter to obtain Mangiferin-berberine composition solution, concentration 4%. This solution is very stable.

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PUM

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Abstract

The present invention relates to one kind of mangiferin-berberine composition with relatively high water solubility and its preparation process and medicinal application. The mangiferin-berberine composition has water solubility up to 25 mg/ml. Animal test shows that the mangiferin-berberine composition has functions of inhibiting bacteria, lowering blood sugar, diminishing inflammation, protecting liver, etc. The mangiferin-berberine composition may be used in preparing eye drops, medicine for women's vaginal diseases, medicine for lowering blood sugar and medicine for treating hepatitis.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a mangiferin-berberine composition with relatively high solubility in water, a preparation method of the composition and its application as medicine. Background technique [0002] Mangiferin is an active ingredient of Chinese herbal medicines such as mango leaves, almond leaves, and Anemarrhena. The literature [Guangxi Institute of National Medicine Yu Shengmin. Advances in the pharmacological research of mangiferin. Chinese Traditional Medicine Science and Technology, 1999, 6 (3)] reported that mangiferin It has various physiological activities and pharmacological effects: (1) the effect on the central nervous system; (2) the effect on the cardiovascular system; (3) the effect of protecting the liver and promoting gallbladder; (4) the effect of anti-lipid peroxidation; (5) ) antiviral effect; (6) immune, anti-inflammatory, analgesic effect. The water solubility of mang...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P1/16A61P3/10A61P15/02A61P27/02A61K31/4375
Inventor 李学坚邓家刚覃振林
Owner 广西中医学院
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