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Method for abstracting active ingredient of meletin in folium ginkgo with ultrasound wave

An active ingredient and ultrasonic technology, which is applied in the field of ultrasonic extraction of quercetin, an active ingredient in ginkgo biloba leaves, can solve the problems of non-selective extraction of target compounds, large industrial pollution, and long extraction time, so as to improve the processing capacity and efficiency of the equipment , wide adaptability, simple and easy operation

Inactive Publication Date: 2008-04-02
NINGBO INST OF TECH ZHEJIANG UNIV ZHEJIANG
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Problems solved by technology

Traditional extraction methods have defects such as long extraction time, complicated process, low

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  • Method for abstracting active ingredient of meletin in folium ginkgo with ultrasound wave

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[0013] The best technical solution obtained is:

[0014] The fresh ginkgo leaves were dried at 60°C for 24 hours, crushed, and sieved (0.45μm) as materials. Put into the ultrasonic extraction kettle and add 45% ethanol aqueous solution, the ratio of material to liquid (Kg:L) 1:14-15, and mix. Ultrasonic generation method: it is excited ultrasonic sound device, radial vibrating cylindrical transducer; ultrasonic power: 100W; ultrasonic frequency: 28kHz; extraction method: interval 5min, ultrasonic action once, ultrasonic action time 3min, total extraction time 32min; extraction Temperature: 45°C; Stirring method: Air-lift stirring; According to the above method, the extraction rate of quercetin, the active ingredient in Ginkgo biloba leaves, can reach 96.28%.

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Abstract

The present invention relates to an extraction technology of effective components in Chinese medicine. Specifically, the present invention relates to a novel method of using ultrasound to extract an effective component quercetin in ginkgo leaves. The method uses a design program of orthogonal experiment. Based on technical parameters of the generation method, ultrasonic intensity, functional duration, functional method, solvent type, temperature of the system, and the mixing method of ultrasound through screening and extraction process, the fresh ginkgo leaves can be prepared. The ginkgo leaves are dried at a temperature of 60 DEG C for 24 hours and crushed and screened (0.45 Mu m) to be a material. The ginkgo leaves are filled into ethanol solution of 45 percent in an ultrasonic extraction reactor; the material and solution are mixed according to a ratio (Kg: L) of 1 to from 14 to 15. The generation method of ultrasound comprises a simulated audible device of ultrasound and a radial cylindrical vibration transducer. The ultrasonic power is 100W, and the ultrasonic frequency is 28 kHz. In the extraction method, the ultrasound functions once with an interval of 5 minutes; the functional time of ultrasound is 3 minutes; the total extraction time is 32 minutes; the extraction temperature is 45 DEG C; the stirring method is an air-lift stirring way. With the methods, the extraction rate of the effective component quercetin in ginkgo leaves can reach 96.28 percent.

Description

1. Technical Field [0001] The invention relates to a new technology for extracting effective components of traditional Chinese medicines, in particular to a new method for extracting the effective components of quercetin from ginkgo biloba leaves using ultrasonic waves. 2. Background technology [0002] The chemical meaning of extraction is to use a suitable solvent and a suitable method to extract the required components from the sample material as completely as possible to avoid or reduce the extraction of harmful components or other impurities. Extracting chemical components from plants for medicinal purposes has a history of nearly 5,000 years in the traditional medicine of the motherland. Traditional extraction methods can be divided into two categories according to the different energy requirements of the extraction process. One type is heating extraction method, which mainly includes different methods such as decoction extraction method, reflux extraction method and Soxhle...

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Application Information

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IPC IPC(8): C07D311/30A61K36/16A61K127/00
Inventor 王强阮晓
Owner NINGBO INST OF TECH ZHEJIANG UNIV ZHEJIANG
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