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Chloromycetin eyedrops with long quality guaranteed period and preparation method thereof

A technology of chloramphenicol and shelf life, applied in the field of chloramphenicol eye drops containing bamboo leaf antioxidants and preparation thereof, can solve problems such as unfavorable use by patients, shelf life can only reach one year and the like

Inactive Publication Date: 2010-04-21
张咏梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patent CN1872038A has introduced dropping pill type chloramphenicol eye drops and preparation method thereof, and it isolates chloramphenicol and aqueous solution by preparing the main drug chloramphenicol into the form of dropping pills, thereby reaching the purpose of prolonging the period of validity of the medicine, but Because the solubility of chloramphenicol in water is slightly soluble, the above-mentioned drugs must be shaken for a long time to dissolve chloramphenicol when used, which is not conducive to the use of patients
[0004] Chinese patent CN1163266C discloses a kind of eye drops for the treatment of conjunctivitis and keratitis eye disease, it improves its anti-staphylococcus aureus, escherichia coli sterilization rate, but the shelf life of the above products can only reach one year

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take 2.5 grams of chloramphenicol, 1.5 grams of boric acid, 0.5 grams of borax, 6.5 grams of sodium chloride, and 0.1 grams of bamboo leaf antioxidants, add water to 1000 milliliters, and the pH of the solution is 6.3.

Embodiment 2

[0029] Take 2.5 grams of chloramphenicol, 1.5 grams of boric acid, 0.5 grams of borax, 6.5 grams of sodium chloride, and 0.3 grams of bamboo leaf antioxidants, and add water to 1000 milliliters.

Embodiment 3

[0031] Take 2.5 grams of chloramphenicol, 1.5 grams of boric acid, 0.5 grams of borax, 6.5 grams of sodium chloride, and 0.5 grams of bamboo leaf antioxidants, and add water to 1000 milliliters.

[0032] Embodiment 1 result is as shown in table 1:

[0033] Table 1:

[0034]

[0035] Embodiment 2 result is as shown in table 2:

[0036] Table 2:

[0037]

[0038] Embodiment 3 results are as shown in table 3:

[0039] table 3:

[0040]

[0041] Examples 1-3 show that when the antioxidant content of bamboo leaves is 0.01-0.05%, the present invention can be realized.

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PUM

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Abstract

The invention discloses a chloramphenicol eye drop with a long guarantee period, which comprises chloramphenicol, buffer solution, and water, wherein the solution contains an anti-oxide (AOB) with theweight concentration of 0.01-0.05% which contains bamboo leaves with the weight concentration of 0.01-0.05%. The invention of the chloramphenicol eye drop can be made up not only according to currentmanufacturing techniques but also the preparation process which comprises a preparation procedure and an encapsulation procedure. The invention has a guarantee period of more than two years comparedwith the prior technique, and the invention facilitates the production, sale, and use of the chloramphenicol eye drop and provides great benefits to the development of a conservation-oriented society.

Description

technical field [0001] The invention belongs to chloramphenicol eye drops and a preparation method thereof, in particular to chloramphenicol eye drops containing bamboo leaf antioxidants and a preparation method thereof. Background technique [0002] Chloramphenicol eye drops is a commonly used drug for the eyes. It is a drug recorded in the second part of the "Chinese Pharmacopoeia" in 2005. It was once used as an OTC Class A drug in the market. Its main ingredients are chloramphenicol, Buffers, bacteriostats, water, and sodium hyaluronate and glycerin are also added to chloramphenicol eye drops to enhance viscosity and improve retention time in the eyes. The usual shelf life of medicines is 2 years, but the shelf life of chloramphenicol eye drops can only reach 8-12 months, this is because chloramphenicol in chloramphenicol eye drops is easily decomposed into chloramphenicol Nitrobenzaldehyde, chloramphenicol diol and p-nitrobenzaldehyde are highly irritating to the eyes ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/165A61K47/46A61P27/02
Inventor 张咏梅
Owner 张咏梅