Anti-depression medicament as well as preparation method and application thereof

An antidepressant and drug technology, which is applied in the field of preparation of antidepressant drugs, can solve the problems of no effect of neurotransmitters, large side effects, causing mania, stimulant effects similar to opioids, etc.

Inactive Publication Date: 2009-01-21
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the 1930s, treatment methods based on electroconvulsive and insulin shock therapy were difficult for patients and their families to accept; in the early 1950s, prohydrazine was used to improve depressive symptoms, but because it could cause mania, there were stimulants similar to opioids. In 1952, chlorpromazine came out, and because of its rapid curative effect, it was widely used soon; in 1957, Swiss scientist Kang Lei Nuo synthesized a drug imipramine with a chemical structure similar to chlorpromazine, It has a good antidepres

Method used

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  • Anti-depression medicament as well as preparation method and application thereof
  • Anti-depression medicament as well as preparation method and application thereof
  • Anti-depression medicament as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh 10kg of Gardenia jasminoides, extract it with water, and purify the extract through XDA-1 macroporous resin. Rinse with water at a flow rate of 10 Br / h, discard the eluate, and then elute with 25 times the column volume of 20% ethanol at a flow rate of 5 Br / h. Collect this part of the eluate and concentrate under reduced pressure to obtain effective fraction I.

[0025] Separately weigh 20kg Rhizoma Rhizoma Cyperi, 20kg Rhizoma Chuanxiong and 20kg Atractylodes Atractylodes, crush them into fine powder, add 6 times the amount of ethanol, soak for 0.5h, heat and reflux for extraction for 2h, filter the extract, recover the solvent from the filtrate, and concentrate until it has no alcohol smell. Add 8 times the amount of water to suspend evenly, centrifuge, separate the insoluble part, and dry to obtain the effective fraction II.

[0026] Mix the effective fraction I and the effective fraction II evenly to obtain the extract. Add appropriate amount of micropowder s...

Embodiment 2

[0028] Weigh 10 kg of Gardenia jasmine, extract with 60% ethanol, recover the ethanol from the extract under reduced pressure until it has no alcohol smell, and carry out purification treatment through XDA-1 macroporous resin, the flow rate of the sample is 2.5Br / h, and the concentration of the sample is geniposide 8mg / ml, wash with 10 times column volume of water first, flow rate 10Br / h, eluate is discarded, and then eluted with 30 times column volume 20% ethanol, flow rate 5Br / h, collect this part of eluate, reduce Concentrate under pressure to obtain effective fraction I.

[0029] Separately weigh 20kg Cyperus cyperi, 20kg Chuanxiong and 20kg Atractylodes atractylodes, crush them into fine powder, add 6 times the amount of ethanol, soak for 0.5h, heat and reflux for extraction for 2 hours, filter the extract, add 6 times the amount of ethanol, heat and reflux for extraction After 1h, the filtrates were combined, the solvent was recovered, and concentrated until there was no...

Embodiment 3

[0032]Weigh gardenia 20kg, extract with water, the extract is purified by XDA-1 macroporous resin, the flow rate of the sample is 2.5Br / h, the concentration of the sample is 8mg / ml in terms of geniposide, firstly the column volume is 10 times Rinse with water at a flow rate of 10 Br / h, discard the eluate, and then elute with 25 times the column volume of 20% ethanol at a flow rate of 5 Br / h. Collect this part of the eluate and concentrate under reduced pressure to obtain effective fraction I.

[0033] Separately weigh 20kg Cyperus cyperi, 20kg Chuanxiong and 20kg Atractylodes atractylodes, crush them into fine powder, add 6 times the amount of ethanol, soak for 0.5h, heat and reflux for extraction for 2 hours, filter the extract, add 6 times the amount of ethanol, heat and reflux for extraction After 1h, the filtrates were combined, the solvent was recovered, and concentrated until there was no alcohol smell. Add 10 times the amount of water to suspend evenly, centrifuge, sepa...

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Abstract

The invention discloses an antidepressant drug and is that gardenia (parched) water or alcohol extraction is mixed with pharmaceutically suitable carrier through the mixture of macroporous resin isolation and purification part (effective part I) and cyperus tuber (vinegar bake), Chuanxiong rhizome and Chinese atractylodes (parched) ethanol extraction water-insoluble fraction (effective part II); then mixture is prepared into various preparation. The invention also discloses the preparation method and the medical application of the antidepressant drug.

Description

technical field [0001] The present invention relates to an antidepressant medicine. The present invention also relates to the preparation method of the antidepressant; in addition, the present invention also relates to the medical application of the antidepressant. Background technique [0002] Depression refers to a class of psychological disorders with significant and persistent low mood, decreased activity, and slowed thinking and cognitive functions as the main clinical symptoms. With the aggravation of many emergency factors, depression has become a common disease in modern society, with a high incidence rate, and its incidence rate is rising rapidly. Currently, depression ranks fourth among the top 10 diseases in the world, and is expected to jump to second place by 2020, second only to ischemic heart disease. WHO pointed out that the biggest illness facing mankind in the 21st century is mental illness, and depression is the focus of it. The prevention and treatment...

Claims

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Application Information

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IPC IPC(8): A61K36/8905A61P25/24
Inventor 尉小慧翟卫峰周吉燕王峥涛胡之璧
Owner SHANGHAI UNIV OF T C M
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