Application of norisoboldine in preparing medicament for treating autoimmune disease

Abstract

The invention relates to the medicine filed, in particular to a medicinal purpose of norisoboldine. The medicinal purpose is characterized in that the norisoboldine can be used in the application of preparing drugs for the treatment of autoimmune diseases. The autoimmune diseases are: rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, multiple sclerosis, type-I diabetes, psoriasis, ulcerative colitis, Sjogren syndrome, scleroderma, polymyositis, chronic active hepatitis, mixed connective tissue disease, primary biliary cirrhosis, autoimmune hemolytic anemia and other diseases.

Description

technical field The invention relates to the field of medicine, in particular to the medical application of norisoboldine. Background technique Autoimmune disease is a common clinical disease caused by abnormal immune response, including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, type I diabetes, psoriasis, ulcerative colitis, etc. disease. Among them, rheumatoid arthritis is a disease dominated by non-suppurative inflammation of multiple joints with peripheral symmetry, often accompanied by inflammation of the synovial membrane of the joint cavity, hyperplasia of synovial tissue, formation of granuloma, destruction of cartilage and bone tissue, and finally joint deformation. ,Loss of function. Multiple sclerosis is an autoimmune disease characterized by inflammatory demyelinating lesions of the central nervous system. Drugs for the treatment of rheumatoid arthritis mainly include non-steroidal anti-inflammatory drugs (diclofenac, aspirin, etc...

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Problems solved by technology

So far, there are no reports on the biological activity or clinical application of noribordine except for the in vitro antioxidant effect [Acta Pharmacina Sinica 200641(10):956-962]

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