Process for producing pericarpium granati total phenols and uses thereof

A technology of pomegranate peel and total phenols, which is applied in the preparation of antibacterial and antioxidant drugs, extraction and purification of a kind of pomegranate peel total phenols with antibacterial activity, can solve the problem of no total phenols in pomegranate peel, etc., to overcome the large toxicity and side effects , good antibacterial activity

Inactive Publication Date: 2009-05-13
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] After patent search, there is no literature similar to the present invention on the preparation of total phenols from pomegranate peel and its application in antibacterial activity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Collect 1 kg of fresh pomegranate peels, wash and crush them, add 10 times the amount of extraction solvent water to the crushed pomegranate peels, soak and extract 3 times at a temperature of 20°C for 0.5 hours, filter, combine the filtrates, and remove the medicinal residues;

[0026] Concentrate the extract at a temperature of 30° C. and dry in vacuum to obtain a total phenolic extract of pomegranate peel, wherein the total phenolic content reaches 38%, and the ellagic acid content is 4%.

Embodiment 2

[0028] Collect 1 kg of fresh pomegranate peels, wash and crush them, add 12 times the amount of extraction solvent water to the crushed pomegranate peels, soak and extract twice at room temperature for 1 hour, filter, combine the filtrates, and remove the medicinal residues;

[0029] Concentrate the extract at a temperature of 40°C until there is no ethanol smell, add 1 times the amount of water to dilute, pass through the D101 macroporous adsorption resin, wash off impurities with 2 times the volume of water, and then use 5 times the volume concentration to 30 % ethanol solution for elution, and the effluent was concentrated under reduced pressure and dried to obtain the purified total phenols of pomegranate peel, the total phenol content reached 65%, and the ellagic acid content reached 26%.

Embodiment 3

[0031] Collect 1 kg of fresh pomegranate peels, wash and crush them, add 20 times the amount of extraction solvent concentration of 20% ethanol solution to the crushed pomegranate peels, soak and extract 3 times at a temperature of 30 ° C, each time for 1 hour, filter, and combine the filtrates to remove the drug. slag;

[0032] The extract is concentrated at a temperature of 35° C., spray-dried in a low-temperature vacuum to obtain a total phenolic extract of pomegranate peel, wherein the total phenolic content reaches 22%, and the ellagic acid content is 2%.

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Abstract

The invention relates to a preparation method and the application for pomegranate hull total phenols with antibacterial activity. The method comprises the following steps: the fresh pomegranate hulls are cleaned, crushed and dried to obtain the pomegranate hull total phenols by a solvent-extraction method or to obtain the purified substance of the pomegranate hull total phenols after being diluted with water by adsorption-desorption of macroporous absorbent resin, concentration and drying. The pomegranate hull total phenols obtained by adopting the method has good antibacterial activity and antioxdant activity, is particularly suitable for the medicinal field and the health-care field, can be used for producing drugs with bacteriostasis, oxidation resistance and anticancer action or auxiliary agents and overcomes the defects of high toxicity and side-effect and high price of the artificially synthesized antibiotics and the Western medicine reagent; and meanwhile, the pomegranate hull total phenols provides a useful way for comprehensive development and utilization of the pomegranate hull resources.

Description

technical field [0001] The present invention relates to the fields of medicine and health care, in particular to an edible plant extract and its application field, in particular to a method for extracting and purifying total phenols of pomegranate peel with antibacterial activity from pomegranate peel, and the pomegranate peel obtained by the method The use of total phenols in the preparation of antibacterial and antioxidant drugs, or auxiliary agents of such drugs to treat various gynecological diseases and cancers. Background technique [0002] Gynecological diseases refer to diseases caused by infections of the female reproductive system. Due to the particularity of female reproductive organs, coupled with factors such as heavy work and social pressure, gynecological diseases are on the rise year by year. The clinical manifestations are various, the etiology is complex and often accompanied by a variety of serious complications, which have a great impact on women's life a...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/185A61P31/04A61P35/00A61P39/06A61K131/00
Inventor热依木古丽·阿布都拉阿吉艾克拜尔·艾萨仲婕罗玉琴
OwnerXINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI