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Improved tissue maintenance

A tissue and composition technology, applied in the direction of drug combination, preservation of human or animal body, medical preparation containing active ingredients, etc., to achieve the effect of preventing fatal arrhythmia, preventing local damage and inflammation

Inactive Publication Date: 2009-08-05
HIBERNATION THERAPEUTICS LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Current technology still results in a significant number of patients suffering from postoperative atrial fibrillation
Post-surgery patients typically require several days of intensive care and take time to regain wakefulness and mobility

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0119] Merely to illustrate the invention by way of example, the following experimental design was carried out. This trial design utilizes a small volume of cardioplegia as described above, where the microvolume is titrated directly onto the heart using the patient's own oxygenated blood. Reference to "setting" is a measure of the amount of substance on a pump, such as a syringe pump, to be delivered directly to an organ, which in this example is the heart.

[0120] Prepare two boxes as follows.

[0121] (1) Arrest Cassette:

[0122] 1. 40ml undiluted potassium with 80mEq - equivalent to 2mEq / ml;

[0123] 2. High setting: 25mEq's / liter;

[0124] 3. Low setting: 10mEq's / liter;

[0125] Potassium in item 1 above is the main cardioplegia agent. Hyperpotassium is the best known and most commonly used cardioplegia solution, despite its known disadvantages and deleterious side effects. An alternative cardioplegia solution is disclosed in WO 00 / 56145 (GP Dobson) comprising a po...

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PUM

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Abstract

The invention provides a method of reducing damage to a tissue, organ or cell from surgical procedures comprising administering a composition comprising a potassium channel opener / agonist and / or an adenosine receptor agonist (eg. adenosine) together with a local anaesthetic (eg. lignocaine) when perfusing the organ.

Description

technical field [0001] The present invention relates to the protection and preservation of tissues following interruption of normal metabolic fluids, such as for the heart during asystole. The invention also relates to methods for improving the recovery of post-operative patients after surgery. In particular, the present invention is particularly useful for minimizing postoperative complications after cardiac surgery, especially after cardiac arrest directly to the heart rather than to the whole body. Background technique [0002] Millions of people around the world choose to undergo open heart surgery each year, 1 to 3% of patients will die in the recovery room, 10% of patients will stay in the hospital with left ventricular dysfunction, and up to 30% of patients will suffer from heart failure. arrhythmias and 24% of high-risk patients will die within 3 years. Moreover, a recent prospective study showed that patients with slightly elevated levels of creatine kinase (CK-MB...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N1/02A61K31/167A61K31/7076A61K33/06A61P41/00A61K33/14
Inventor 杰弗里·菲利普·多布森
Owner HIBERNATION THERAPEUTICS LTD
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