Chinese medicinal granule for treating endometriosis uterine and preparation method thereof

A technology of traditional Chinese medicine granules and endometrium is applied in the directions of pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients to achieve the effect of reducing the amount of excipients

Inactive Publication Date: 2009-09-30
SHANGHAI INST OF PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because traditional Chinese medicine extracts are easy to absorb moisture, the traditional wet granulation process usually needs to add a lot of excipients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The raw material prescription is:

[0026] Astragalus 30g; Salvia miltiorrhiza 20g; Raw Puhuang 24g; Wulingzhi 15g; Myrrh 6g;

[0027] Preparation of granules:

[0028] Take salvia miltiorrhiza, myrrh, curcuma, three-edged and four-flavored medicinal materials, add 95% ethanol to reflux to extract twice, filter, concentrate the filtrate to thick, add appropriate amount of micro-powder silica gel to absorb to obtain dry powder, medicine dregs mixed with astragalus, raw cattail, five Mix lingzhi, red rattan, and Patrinia, add water to decoct twice, filter, concentrate the filtrate to an appropriate amount, and spray dry to obtain a water-extracted dry powder. Mix the two dry powders to make an extract powder, and add the extract powder 10% lactose by weight, mixed uniformly, the mixed powder is compressed into tablets by a dry granulator, and crushed to obtain the product.

Embodiment 2

[0030] The raw material prescription is:

[0031] Astragalus 15g; Salvia miltiorrhiza 10g; Raw Puhuang 12g; Wulingzhi 8g; Myrrh 3g;

[0032] Preparation of granules:

[0033] Take salvia miltiorrhiza, myrrh, curcuma, three-edged and four-flavored medicinal materials, add 95% ethanol to reflux extraction for 3 times, filter, concentrate the filtrate to thick, add appropriate amount of micro-powder silica gel to absorb to obtain dry powder, medicine dregs and astragalus, raw cattail, five Mix lingzhi, red rattan, and Patrinia, add water to decoct 3 times, filter, concentrate the filtrate to an appropriate amount, and spray dry to obtain a water-extracted dry powder. Mix the two dry powders to make an extract powder, and add the extract powder 15% by weight of microcrystalline cellulose, mixed uniformly, the mixed powder is compressed into tablets by a dry granulator, and pulverized to obtain final product.

Embodiment 3

[0035] The raw material prescription is:

[0036] Radix Astragalus 45g; Salvia miltiorrhiza 10g; Raw Puhuang 36g; Wulingzhi 8g; Myrrha 9g;

[0037] Preparation of granules:

[0038] Take salvia miltiorrhiza, myrrh, curcuma, three-edged and four-flavored medicinal materials, add 95% ethanol to reflux extraction for 3 times, filter, concentrate the filtrate until thick, add an appropriate amount of micro-powder silica gel to absorb to obtain a dry powder, the dregs are mixed with sunburned astragalus, raw cattail, Mix Wulingzhi, red rattan, and Patrinia, decoct twice with water, filter, concentrate the filtrate to an appropriate amount, and spray dry to obtain a water-extracted dry powder. Mix the two dry powders to make an extract powder, and add the extract 15% compressible starch by weight of the powder, mixed uniformly, pressed the mixed powder into tablets with a dry granulator, and pulverized to obtain the product.

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PUM

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Abstract

The invention discloses a Chinese medicinal granule for treating endometriosis uterine. The mixture ratio of raw materials of the granule is (calculated as the dosage of crude drugs): 15 to 45 g of radix astragali or astragalus root, 10 to 30 g of danshen root, 12 to 36 g of raw cattail pollen, 8 to 25 g of trogopterus dung, 3 to 9 g of myrrh, 5 to 25 g of trigone, 5 to 25 g of rhizoma zedoariae, 15 to 45 g of sargentgloryvine stem, and 15 to 45 g of herba patriniae. The granule also comprises an excipient. The invention also discloses a method for preparing the granule, which comprises the following steps that: (1) various medicinal materials are prepared into extract powder; (2) the excipient is added into the extract powder, and the mixture is mixed evenly; and (3) the tabletting and the crushing pelletization are performed. Compared with the prior art, a production method of the Chinese medicinal granule is simple, does not need to heat, and has less dosage of excipients, and the granule is convenient for patients to use.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a traditional Chinese medicine granule for gynecology. Background technique [0002] Endometriosis is a lesion caused by the endometrium growing outside the uterine cavity. It has the characteristics of strong invasiveness, extensive planting, and easy recurrence. The discovery of this disease has been more than 100 years so far, but the etiology of this disease is still not very clear. [0003] From the perspective of traditional Chinese medicine, endometriosis belongs to the categories of "dysmenorrhea", "infertility" and "abdominal lumps". Revised as blood stasis. The essence of blood stasis belongs to the category of blood circulation disorder in modern pathophysiology. Longer, it damages righteousness, qi and blood interact, qi stagnation due to deficiency, stagnation due to deficiency, stagnation from stagnation, qi deficiency and blood stasis cause and effect each o...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/906A61K9/16A61K47/26A61K47/34A61K47/36A61P15/00A61K35/24A61K47/32A61K47/38
Inventor陆伟根李军虞丽芳周俊
OwnerSHANGHAI INST OF PHARMA IND CO LTD