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Application of diterpene compounds in rabdosia japonica to preparation of anti-hepatitis virus medicines

A technology of compounds and diterpenoids, which is applied in the field of preparation of anti-hepatitis drugs, can solve problems such as no anti-hepatitis virus effect

Inactive Publication Date: 2009-10-07
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0012] So far, there is no relevant report about the anti-hepatitis virus effect of the above compounds

Method used

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  • Application of diterpene compounds in rabdosia japonica to preparation of anti-hepatitis virus medicines
  • Application of diterpene compounds in rabdosia japonica to preparation of anti-hepatitis virus medicines

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Embodiment Construction

[0016] Now in conjunction with in vitro experiments, the present invention will be described in detail.

[0017] Anti-hepatitis B virus test of Elyculin B, Elyculin C, Elyculin D, Elyculin and Elyculin:

[0018] 1. Experimental drugs, reagents and materials

[0019] 1. Compounds: Elelysin B, Elysine C, Elysine D, Elysine E, and Elysine hexan are extracted and isolated from Elephantia japonica, see [Gui Mingyu, et al. Study on the Chemical Constituents of Rabdosia japonica II, Chinese Journal of Pharmaceutical Sciences, 2000; 35(6): 375; Zhao Bao Xiang (xiang Zhaobao), Hai Sheng Chen (Chen Haisheng), et al.Two new diterpenoids from Rabdosia japonica var.glaucocalyx , Chinese Chemical Letter2008; 19:852-854; Zhao Bao Xiang (xiang Zhaobao), Hai Sheng Chen (Chen Haisheng), et al.Diterpenoids from Rabdosia japonica Asian Journal of Chemistry2009; 21:3;].

[0020] 2. Licanread HBsAg Diagnostic Kit (Shanghai Kehua Biotechnology Co., Ltd.)

[0021] 3. Readable HBeAg diagnostic kit ...

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Abstract

The invention relates to the technical field of medicine and the application of diterpene compounds, including glaucocalyxin B, glaucocalyxin C, glaucocalyxin D, glaucocalyxin E and glaucocalyxin F in rabdosia japonica, to preparation of anti-hepatitis virus medicines. The invention performs anti-hepatitis B surface antigen and hepatitis B core antigen experiments of diterpene compounds including glaucocalyxin B, glaucocalyxin C, glaucocalyxin D, glaucocalyxin E and glaucocalyxin F by a hepatitis B surface antigen (HBsAg) diagnostic kit and a hepatitis B core antigen (HBeAg) diagnostic kit. The result shows that these compounds have obvious anti-hepatitis B virus activity, thus, these compound can be used for preparation of anti-hepatitis B virus medicines.

Description

technical field [0001] The present invention relates to the technical field of medicine, and relates to the application of diterpenoids lamina, lamina, lamina, lamina, and lamina in the preparation of anti-hepatitis drugs . Background technique [0002] Glaucocalyxin B, Glaucocalyxin C, Glaucocalyxin D, Glaucocalyxin E, and Glaucocalyxin F are from Lamiaceae Kaurane-type diterpenoids isolated from the whole herb of Rabdosia japonica (Burm.f.) Hara var. glaucocalyx (Maxim.) Hara [Gui Mingyu, et al. Study on the Chemical Constituents of Rabdosia japonica II, Chinese Journal of Pharmaceutical Sciences, 2000; 35(6): 375; Zhao Bao Xiang (xiang Zhaobao), Hai Sheng Chen (Chen Haisheng), et al.Two new diterpenoids from Rabdosia japonica var.glaucocalyx , Chinese Chemical Letter 2008; 19: 852-854]. [0003] Their general chemical structures are as follows: [0004] [0005] Among them, the group R 1 Selected from H, COCH 3 ; 2 Selected from COCH 3 , H; R 3 selected from H...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61P1/16A61P31/12
Inventor 陈海生项昭保刘建国金永生赵卫权
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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