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Application of ginsenosides Rg1, Rh1 and Ppt to resistance of cognitive competence and study memory function disorders

A technology for cognitive dysfunction and ginsenosides, applied in the field of application of ginsenosides Rg1, Rh1 and Ppt against cognition, learning and memory dysfunction

Inactive Publication Date: 2009-10-07
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the role of the metabolites Rh1 and Ppt of ginsenoside Rg1 in regulating synaptic plasticity and improving cognitive function and learning and memory functions, and the comparison with the strength of the prototype Rg1 has not been reported so far.
[0005] In addition, regarding the research on ginsenosides, there has always been a controversial issue in the academic circles, that is, whether ginsenosides play a role in their prototype or their metabolites.

Method used

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  • Application of ginsenosides Rg1, Rh1 and Ppt to resistance of cognitive competence and study memory function disorders
  • Application of ginsenosides Rg1, Rh1 and Ppt to resistance of cognitive competence and study memory function disorders
  • Application of ginsenosides Rg1, Rh1 and Ppt to resistance of cognitive competence and study memory function disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Example 1 Ginsenoside Rg1 and its metabolites Rh1 and Ppt improve basic synaptic transmission and induce the formation of LTP

[0072] Objective: To observe the effects of ginsenoside Rg1 and its metabolites Rh1 and Ppt on basic synaptic transmission and LTP induction.

[0073] 1.1. Materials and methods

[0074] 1.1.1. Experimental animal SD rats, male (body weight 250-300 grams), purchased from China National Institute for the Control of Pharmaceutical and Biological Products (certificate number SCXK (Beijing) 2005-0004), animals were raised in alternating light and dark (12h: 12h) In a clean animal room, free access to food and water. Animals were acclimated to the environment in the animal room for 5 days before the experiment.

[0075] 1.1.2. Experimental equipment SEN-7203 three-channel electronic stimulator: (Nihon Kohden Co., Japan), VC-11 memory oscilloscope: (same as above), SS-202J stimulation isolator: (same as above), SR-6N stereotaxic Instrument (Narish...

Embodiment 2

[0093] Example 2 The effect of ginsenoside Rg1 and its metabolite Ppt on the maintenance phase of LTP induced by high-frequency stimulation

[0094] Objective: The consolidation effect of ginsenoside Rg1 and its metabolite Ppt on the maintenance phase of LTP induced by high-frequency stimulation

[0095] 2.1. Materials and methods

[0096] Experimental animals and experimental equipment are the same as in Example 1.

[0097] experimental method

[0098] The embedding of the electrodes, the recording of the evoked potential and the calculation method of its amplitude, as well as the data analysis and statistics are the same as those in Example 1.

[0099] Tetanic stimulation parameters: LTP in the granule cell layer of the dentate gyrus of the hippocampus was induced by 10 series of 100Hz HFS, each series of stimulation was composed of 5 square waves with a width of 0.2ms and a frequency of 100Hz, the interval between series of stimulations was 200ms, and the stimulation inte...

Embodiment 3

[0110] Example 3 Improvement effect of ginsenoside Rg1 and its metabolites Rh1 and Ppt on scopolamine-induced learning and memory impairment in mice

[0111] Objective: To observe the effects of ginsenoside Rg1 and its metabolites Rh1 and Ppt on learning and memory impairment in mice induced by scopolamine

[0112] 3.1. Materials and methods

[0113] 3.1.1. Experimental animal KM mice, male (body weight 18-22 grams), were purchased from the Institute of Experimental Animals, Chinese Academy of Medical Sciences (certificate number SCXK (Beijing) 2004-0001), and the animals were raised in alternating light and dark (12h: 12h ) in a clean animal room, free to eat and drink. Animals were acclimated to the environment in the animal room for 3 days before the experiment.

[0114] 3.1.2. Experimental Instruments

[0115] Mouse dark avoidance test recorder (model PA M5, Taisho Pharmaceutical Co., Ltd., Japan). Mouse water maze apparatus (Institute of Materia Medica, Chinese Academ...

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Abstract

The invention discloses an application of ginsenoside Rg1, Rh1 and Ppt to the resistance of cognitive competence and study memory function disorders, in particular relates to an application of ginsenoside Rg1 and / or metabolites thereof, such as Rh1 and / or Ppt to the preparation of medicines and health products preventing, relieving and / or curing diseases or symptoms capable of causing the cognitive competence disorders and / or the study memory function disorders, particularly the Alzheimer's disease (AD). The invention is applied to the preparation of the medicines and the health products improving the cognitive competence and the study memory function.

Description

technical field [0001] The invention relates to the effect of improving learning and memory behavior and improving neuroplasticity of metabolites Rh1 and Ppt of ginsenoside Rg1 and the effect of Rg1 improving neuroplasticity. The present invention relates to ginsenoside Rg1 and / or its metabolite Rh1 and / or Ppt are used for preventing, alleviating and / or treating and can cause cognitive function and / or learning and memory dysfunction such as Alzheimer's disease (AD, Alzheimer's disease ) and other diseases or symptoms of medicines or health care products; also relates to containing the ginsenoside Rg1 and / or its metabolites Rh1 and / or Ppt for the preparation of prevention, alleviation and / or treatment of Alzheimer's disease (AD, Alzheimer's disease (AD, Alzheimer's disease) Moller's disease) and other diseases or symptoms, especially the use of drugs and / or pharmaceutical compositions for improving cognitive function and / or learning and memory function; Background technique ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P25/28A23L1/30A23L33/10
Inventor 王玉珠陈霁楚世峰张均田
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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