Special multichannel syphilis diagnosis device combined with quasi-one-dimensional specific antigen modified electrodes

Abstract

The invention relates to a special multichannel syphilis diagnosis device combined with quasi-one-dimensional specific antigen modified electrodes. The device is a micro-fluidic chip, belonging to the field of analysis test. One of the targets of the relevant diagnosis and treatment technologies is to quickly diagnose syphilis patients with low cost. The invention provides a diagnosis device aiming to achieve the target. The key points of the proposal are that the device, namely the micro-fluidic chip, comprises channels of parallel structure inside, the parallel structure comprises four branch channels mutually connected in parallel, four catenulate working electrodes in total are respectively arranged in the four branch channels, the catenulate working electrode is composed of a conductive electrode and a gold size sensing membrane that attaches onto the conductive electrode and is embedded with the syphilis specific antibody, and the respective gold size sensing membranes on the superficial coats of the four catenulate working electrodes are respectively embedded with four different syphilis specific antibody substances which are respectively syphilis specific antibodies TP0684, TP0453, TP0821 and TP0319.

Description

technical field [0001] The invention relates to a multi-channel special device for syphilis diagnosis combined with a quasi-one-dimensional specific antigen-modified electrode. The syphilis diagnosis device is a special microfluidic chip for diagnosing syphilis antigens based on antigen / antibody specific reactions, and belongs to the field of analysis and testing. Background technique [0002] Syphilis is a sexually transmitted disease (STD) caused by Treponema pallidum (TP). Treponema pallidum only infects humans under natural circumstances, and humans are the only source of infection for syphilis, mainly through sexual contact. It can also be transmitted vertically through the placenta, causing congenital syphilis in the fetus. A small number of people can also be infected by blood transfusion. Since the 1980s, syphilis has revived again in my country. According to statistics from the National Center for STD Control, the annual growth rate of the incidence of syphilis in...

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Problems solved by technology

(4) At present, microfluidic sensors are mostly based on optical detection systems. The instruments are expensive and bulky, and full integration is difficult. Moreover, the detection cost is high, which limits its promotion.

[0006] At present, in the field of microfluidic chip technology, the related technologies and methods of using multiple syphilis-specific antibodies to simultaneously detect and rapidly diagnose multiple syphilis antigens have not been reported.

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