Method for producing nikkomycin Z, special culture medium of nikkomycin Z and special engineering bacteria of nikkomycin Z

A nikkomycin and culture medium technology, applied in the field of nikkomycin Z production, can solve the problems of expensive reagents, unsuitable for large-scale industrial production, inability to effectively separate X components and Z components, etc. The effect of simplifying separation and purification and reducing production costs
CN101591634BActive Publication Date: 2011-02-02INST OF MICROBIOLOGY - CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF MICROBIOLOGY - CHINESE ACAD OF SCI
Publication Date
2011-02-02

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Abstract

The invention discloses recombinant streptomyces ansochromogenes, which are streptomyces ansochromogenes having blocked sanP genes for biologically synthesizing nikkomycins. The recombinant streptomyces ansochromogenes are (Streptomyces ansochromogenes) TH322 sanPD CGMCC No.3086. The invention also provides a method for producing the nikkomycin Z and a culture medium of the nikkomycin Z. In the invention, the recombinant streptomyces ansochromogenes which only produce a single nikkomycin Z component are provided, the culture medium of the nikkomycin Z is optimized, and the recombinant streptomyces ansochromogenes can produce the single component nikkomycin Z in large scale with a yield which is 4.5 times that of the prior initial strain of streptomyces ansochromogenes TH322 and reduce production cost, and have a significant for the simplification of the separation and purification of products obtained after fermentation.
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Description

technical field

[0001] The invention relates to a method for producing nikkomycin Z, its special culture medium and engineering bacteria. Background technique

[0002] Nikkomycin belongs to nucleoside peptide antibiotics, which is similar in structure to UDP-N-acetylglucosamine, the natural substrate of chitin synthase, and is a strong competitive inhibitor of this enzyme. Since chitin is an important part of the cell wall of fungi and the exoskeleton of insects and other invertebrates, nikkomycin can effectively inhibit fungi, insects and mites, and is non-toxic or extremely toxic to mammals, bees and plants Low, and nikkomycin is easy to degrade in nature, so nikkomycin is an ideal agricultural antibiotic. Field experiments have proved that nikkomycin has a good control effect on many plant diseases, such as wheat powdery mildew, tobacco red spot, cucumber sclerotinia, tomato leaf mold, and apple ring spot. At the same time, studies have shown that nikkomycin can effecti...

Claims

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