Establishment method of hypercholesterolemia animal model

A technology of hypercholesterolemia and animal models, applied in animal feed, animal feed, applications, etc., can solve problems that have no direct correlation, reduce modeling time, have good application prospects, improve the success rate of modeling and make Die efficiency effect

Inactive Publication Date: 2010-01-13
TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Abstract
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  • Application Information

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Problems solved by technology

[0003] The above two patent documents are not directly related to this patent application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Animal Model: Rat

[0014] Establishment method of hypercholesterolemia model:

[0015] (1) Basic feed composition: corn starch 508g / Kg, casein 242g / Kg, sucrose 119g / Kg, lard 50g / Kg, mixed minerals (AIN-76 mineral mix) 40g / Kg, mixed vitamins (AIN-76 A vitamin mix) 20g / Kg, gelatin 20g / Kg, DL-methionine 1g / Kg.

[0016] Cholesterol addition amount: 6-20g / Kg.

[0017] (2) The rats were fed with the above-mentioned high-cholesterol mixed feed for 2-6 weeks, and then they showed obvious symptoms of hypercholesterolemia.

Embodiment 2

[0019] Animal Model: Hamster

[0020] Establishment method of hypercholesterolemia model:

[0021] (1) Basic feed composition: corn starch 508g / Kg, casein 242g / Kg, sucrose 119g / Kg, lard 50g / Kg, mixed minerals (AIN-76 mineral mix) 40g / Kg, mixed vitamins (AIN-76 A vitamin mix) 20g / Kg, gelatin 20g / Kg, DL-methionine 1g / Kg.

[0022] Cholesterol addition amount: 1-9g / Kg.

[0023] (2) The hamsters showed obvious symptoms of hypercholesterolemia after being fed the above-mentioned high-cholesterol diet for 2-6 weeks.

[0024] This method is used in the research on the cholesterol-lowering function of functional ingredients, and the functional ingredients can be given to animals for evaluation before, during and after the method described in this patent.

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Abstract

The invention relates to an establishment method of hypercholesterolemia animal model; rat and hamster are selected as animal model, during the model building period, high cholesterol feed is fed to the animal model, and hypercholesterolemia symptom is shown after 2-6 weeks, wherein, the addition of cholesterol in high cholesterol feed is that each kilogram of basal feed is added with 0.1-50g of cholesterol. The establishment method of animal model is safe and reliable, reduces the model building time of the animal model, enhances molding success rate and molding efficiency, and has good application prospect. In addition, the establishment method of animal model can also be used for establishment of hypercholesterolemia model and function assessment of lowering cholesterol of functional components, and the like.

Description

technical field [0001] The invention belongs to a method for establishing an animal model, in particular to a method for establishing an animal model of hypercholesterolemia. Background technique [0002] Nowadays, people build animal models and use scientific methods to find out the etiology of diseases by studying model animals, so as to prevent the occurrence of diseases and fundamentally find ways to cure diseases. Rats (Sprague Dawley rat) and hamsters (Syrain Hamster Mesocricetus Auratus) are recognized as commonly used animal models and are widely used in the experimental research of related diseases. As an important factor leading to coronary heart disease, high blood cholesterol has attracted more and more attention, but through literature search, no patents on animal models of hypercholesterolemia have been found. But found two relevant documents: 1, a kind of construction method of pigment calculus guinea pig animal model, choose the guinea pig that body weight i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/02A01K67/027A23K1/18A23K1/165
Inventor 张泽生王浩
Owner TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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