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Novel preparation method of platelet aggregation inhibition compound

A compound and a new type of technology, applied in the field of new preparation of anti-platelet aggregation compounds, can solve problems such as limitations, free base precipitation, and purification difficulties, and achieve the effects of reducing dosage, shortening reaction cycle, and simplifying operation steps

Active Publication Date: 2010-07-21
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Unstable in case of moisture, it will cause the precipitation of free alkali, and it is difficult to purify
And because of its strong acidity, it will be subject to certain restrictions in preparation

Method used

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  • Novel preparation method of platelet aggregation inhibition compound
  • Novel preparation method of platelet aggregation inhibition compound
  • Novel preparation method of platelet aggregation inhibition compound

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Abstract

The invention belongs to the technical field of pharmaceutical chemistry, and particularly provides a novel preparation method of a compound for preparing platelet aggregation inhibitors with a general formula (I). The preparation route adopts a one-pot method, and the intermediate directly enters the next reaction without being purified or separated. The method can prepare the target compound I in one step. Compared with the synthesis techniques provided in the prior literature, the invention increases the yield, simplifies the operation steps and shortens the production cycle, thereby finally reducing the production cost and meeting the requirements for green synthesis techniques. In the compound I, R is a methyl or ethyl group.

Description

technical field The invention belongs to the technical field of chemical pharmacy, and in particular relates to a novel preparation method of an anti-platelet aggregation compound. Background technique Thrombosis can lead to acute myocardial infarction, stroke, pulmonary embolism and other diseases of the heart, brain, and pulmonary circulation, threatening human health and life, and is also a common complication in surgery and a factor of reocclusion after interventional angioplasty. Although thrombolytic therapy, interventional therapy and even surgical treatment carried out in recent years have made remarkable progress in the treatment of acute myocardial infarction and cerebral infarction, the success rate of patient rescue has been greatly improved, and the quality of life has also been significantly improved, but cardiovascular and cerebrovascular After all, the disability rate is as high as 30%. Therefore, the development of drugs for the prevention and treatment of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D495/04
Inventor 刘登科刘颖刘默刘冰妮黄长江穆帅王平保
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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