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New antibacterial compound

A technology of compounds and hydrates, applied in the preparation of organic compounds, antibacterial drugs, organic chemistry, etc.

Inactive Publication Date: 2011-01-19
GUANGDONG ZHONGKE DRUG R&D
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs have produced different degrees of drug resistance after a period of clinical use, so it is necessary to explore new antibiotics for drug-resistant bacteria

Method used

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Embodiment 1

Embodiment 2

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Abstract

The invention relates to a new compound with significant antibacterial activity, the structure is as follows: (formula I), and the new compound has great antibacterial effect for methicillin resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA). (Formula I).

Description

Technical field: The present invention relates to a new compound for antibacterial effect, which has good antibacterial activity against MRSA and MSSA. Background technique: In recent years, with the widespread use of antibiotics (including humans and animals), the increase in the use of glucocorticoids and immunosuppressants, and the increase in elderly patients, the problem of pulmonary drug-resistant bacterial infections has become increasingly prominent. Penicillin-resistant Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), extended-spectrum beta-lactamase (ESBL)-producing Gram-negative bacteria Wait. Methicillin-resistant Staphylococcus aureus is also a difficult issue. Since the first strain of MRSA was detected for more than 40 years, MRSA infection has been on the rise all over the world. According to the National Nosocomial Infection Surveillance (NNIS) report, 182 hospitals in 1975 MRSA accounte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C237/26C07C231/02A61K31/65A61P31/04
Inventor 苏春华王伟
Owner GUANGDONG ZHONGKE DRUG R&D
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