Extracts of panaxtriol saponins and extraction method thereof

A technology of notoginseng triol group and extract, which is applied in the field of Chinese medicine extract and its preparation, can solve problems such as poor separation effect, achieve the effect of reducing liver microcirculation disorder, novel use, and high purity

Inactive Publication Date: 2011-02-09
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The above methods all use macroporous adsorption resin for separation, and the separation effect is not good. The inventors used C 18 Reversed-phase silica gel column separation, a new group of notoginsengtriol saponin extracts and their preparation methods were tested. These notoginsengtriol saponin extracts have high curative effect, high purity, good absorption, stable quality, and the separation effect of the preparation method Good, high content, simple process, convenient operation, low cost, suitable for industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 10

[0056] The preparation of embodiment 1 notoginseng triol group saponins

[0057] Panax notoginseng, crushed into granules, passed through a 20-mesh sieve, soaked in 6 times of 70% ethanol for 8 hours, installed in a percolation barrel for percolation, collected 30 times the amount of 70% ethanol percolation liquid, and the percolation flow rate was 1BV / h, and the percolation liquid Concentrate under reduced pressure below 70°C to 1.5 times the medicinal material, centrifuge, and concentrate the supernatant to dryness under reduced pressure. The dried sample was passed through a neutral alumina column, eluted with a certain ratio of ethanol and water (volume ratio 1:5), and the end point of elution was judged by TLC. The organic solvent is recovered under vacuum and decompression below 70°C; the concentrated solution is diluted with water to 5 times the volume of the medicinal material, and the sample loading flow rate on the diluted solution is 1BV / h, 7.5 times Column volume,...

Embodiment 3

[0071] Radix Notoginseng, crushed into granules (through a 20-mesh sieve), soaked in 3 times of 70% ethanol for 8 hours, installed in a percolation barrel for percolation, collected 20 times the amount of 70% ethanol percolation liquid, the percolation flow rate is 1BV / h, and percolated The solution was concentrated under reduced pressure below 70°C to 1.5 times that of the medicinal material, centrifuged, and the supernatant was concentrated to dryness under reduced pressure. Dry the sample through a neutral alumina column, elute with acetone and water in a certain ratio (volume ratio 1:1), and judge the elution end point by TLC. The organic solvent is recovered under vacuum and decompression below 70°C; the concentrated solution is diluted with water to twice the volume of the medicinal material, and the sample flow rate of the macroporous anion exchange resin ((resin and medicinal material 0.5: 1g / g) on ​​the diluted solution is 0.5BV / h, 5 Double the column volume, flow rat...

Embodiment 4

[0073] Radix Notoginseng, crushed into granules (through a 20-mesh sieve), soaked in 10 times of 70% ethanol for 8 hours, installed in a percolation barrel for percolation, collected 40 times the amount of 70% ethanol percolation liquid, the percolation flow rate is 1BV / h, and percolated The solution was concentrated under reduced pressure below 70°C to 1.5 times that of the medicinal material, centrifuged, and the supernatant was concentrated to dryness under reduced pressure. Dry the sample through a neutral alumina column, elute with a certain ratio of organic solvent and water (volume ratio 1:10), and judge the elution end point by TLC. The organic solvent is recovered under vacuum and reduced pressure below 70°C; the concentrated solution is diluted with water to 2 to 10 times the volume of the medicinal material, and the sample loading flow rate on the diluent is 1.5BV / h on the macroporous anion exchange resin ((resin and medicinal material 1:1g / g) , 10 times the column ...

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Abstract

The invention relates to extracts of traditional Chinese medicines and preparation thereof, in particular to extracts of panaxtriol saponins, extracts of panax notoginseng and preparation thereof. The preparation process comprises the steps of extraction, separation, concentration and the like.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract and its preparation, in particular to a notoginseng triol saponin extract and its preparation. Background technique [0002] Panax notoginseng (Panax notoginseng, PN) is the air-dried root of the traditional Chinese medicine Panax notoginseng (Burk) F.H.Chen. Panax notoginsenosides (also known as Panax notoginsenosides, English name: Panax Notoginsenosides, PNS) is the main active ingredient of Panax notoginseng, composed of more than 30 different saponins, widely used clinically to treat diseases related to microcirculation disorders , such as cardiovascular disease and liver dysfunction. [0003] Notoginseng saponins have been included in the national pharmacopoeia, and corresponding preparations are on the market, such as Xuesaitong for injection. The main components of notoginsenosides are: ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1. There are many reports on their prep...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P1/16A61P9/00
Inventor李瑞明王玉周水平张兰兰
OwnerTIANJIN TASLY PHARMA CO LTD