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Application of red stilbene and red stilbene polysaccharide in preparing medicament for improvement of learning memory and treatment of Alzheimer disease

A technology of Alzheimer's disease and Hedystilbene polysaccharide, applied in the field of traditional Chinese medicine

Active Publication Date: 2012-07-04
张占军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since there is still no report on the treatment of senile dementia with Radix Radix Radix and Radix Radix Polysaccharides, it is of great value to study their mechanism of protecting brain nerve cells, regulating the secretion of brain neurotransmitters, and preventing and treating senile dementia.

Method used

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  • Application of red stilbene and red stilbene polysaccharide in preparing medicament for improvement of learning memory and treatment of Alzheimer disease
  • Application of red stilbene and red stilbene polysaccharide in preparing medicament for improvement of learning memory and treatment of Alzheimer disease
  • Application of red stilbene and red stilbene polysaccharide in preparing medicament for improvement of learning memory and treatment of Alzheimer disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0173] Embodiment 1: Capsules

[0174] 3340g Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix L. is crushed into fine powder, sieved, and made into capsules. It is used to improve cognitive dysfunction, treat Alzheimer's disease, and increase the content of monoamine neurotransmitters in the brain.

Embodiment 2

[0175] Embodiment 2: capsules

[0176] Take 33g of Radix Radix Polysaccharides, add appropriate amount of auxiliary materials, and make capsules.

Embodiment 3

[0177] Example 3 tablet

[0178] Radix Radix Radix Radixe root is ground, add 10 times the amount of water, and add cellulase (1% amount), adjust pH to 5, decoct twice, each time 2 hours, filter, collect filtrate. Adjust the pH of the filtrate to neutral, concentrate to a relative density above 1.20 (measured at 60°C), add ethanol to make the alcohol content reach 60%, and let stand for 24 hours. Discard the supernatant, collect the precipitate by centrifugation, wash the precipitate twice with ethanol, freeze-dry, crush into a fine powder, add appropriate amount of auxiliary materials, make granules, dry, compress into tablets, and coat with sugar. It is used to improve cognitive dysfunction, treat Alzheimer's disease, and increase the content of monoamine neurotransmitters in the brain.

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Abstract

The invention discloses a novel application of red stilbene and red stilbene polysaccharide in preparing medicament for treatment of Alzheimer disease. Red stibene and red stilbene polysaccharide in the invention can protect SH-SY5Y cells from the damage from A beta 25-35, and increase the viability of SH-SY5Y cells. The Morris water maze test indicates that red stibene and red stilbene polysaccharide can improve the cognitive dysfunction of mice with rapid brain aging and rats injected with A beta and AD in the hippocampus. Further histology detection indicates that red stilbene and red stilbene polysaccharide can increase the contents of center neurotransmitters 5-HT, 5-HIAA, NE and DA in rapid aging mice brain, wherein the neurotransmitters are monoamines.

Description

Technical field: [0001] The invention relates to the application of Radix Radix Radix Radix Radix and Radix Radix Radix Radix Polysaccharide in the preparation of medicines for treating Alzheimer's disease, which belongs to the field of traditional Chinese medicines. technical background: [0002] The issue of "population aging" is a huge challenge that every country in the world will face in the 21st century. There are more than 600 million elderly people in the world (60 years old and above, the same below unless otherwise specified), and by the end of the first half century of the 21st century, that is, by 2050, the world's elderly population will increase significantly to 20%, that is, every 5 people will be One is an elderly person. "Aging" is indeed a challenge in the 21st century. At present, population aging has become an important demographic phenomenon in the process of economic and social development. By the end of 2006, the elderly population in Beijing had re...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/48A61K31/715A61P25/28A61P25/00
Inventor 张占军王永炎朱海燕程卫东
Owner 张占军
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