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Detection method used for predicting occurrence risk of abnormal proliferation or tumors of human body

A detection method and abnormal technology, applied in the detection field, can solve problems such as short course of disease

Inactive Publication Date: 2011-05-11
KEAISE MEDICINE WUHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the cancer cells of breast cancer patients whose Trx is positive in both the nucleus and the cytoplasm proliferate rapidly and have a short course of disease

Method used

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  • Detection method used for predicting occurrence risk of abnormal proliferation or tumors of human body
  • Detection method used for predicting occurrence risk of abnormal proliferation or tumors of human body
  • Detection method used for predicting occurrence risk of abnormal proliferation or tumors of human body

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Example 1 The research on the activity of TrxR and the risk of abnormal hyperplasia or tumor in human body adopts the kit of the present invention to measure the activity of thioredoxin reductase in the blood of 58 cases of normal people and 20 cases of tumor patients in clinical detection, and it is used to predict the occurrence of human body. Risk of abnormal growth or tumor development.

[0061] Table 2 The relationship between TrxR activity and the risk of human abnormal proliferation or tumor occurrence

[0062]

[0063]

[0064]

[0065]

[0066]

[0067]

[0068]

[0069]

[0070] Note: The degree of abnormal hyperplasia is as follows: normal, normal-(requires reexamination or regular inspection), normal--(related to abnormal hyperplasia), TRCA / positive, TRCA+, TRCA++, TRCA+++, TRCA++++, greater than TRCA++++ (TRCA represents the TR level of tumor patients , + represents the degree of TR activity).

[0071] It can be seen from Table 2 ...

Embodiment 2

[0072] Example 2 Study on the relationship between TrxR activity and the risk of human abnormal hyperplasia or tumor occurrence

[0073] The detection method of the present invention is used to predict the risk of abnormal hyperplasia or tumor occurrence of 300 cases, and it is concluded that: more than 70% of the crowd has no abnormality, and their TrxR activity is lower than 1; 1. The total thiol content is above 30; more than 70% of the tumor patients have TrxR activity greater than 30, and the total thiol content does not exceed 30.

[0074] Table 3 Comparison between this method and clinical diagnosis

[0075]

[0076] The data in this table are based on the three groups of absolute clinical normality, absolute clinical evaluation of abnormal hyperplasia, and clinically judged tumor patients among the total number of 300 cases.

[0077] The detection method of the present invention is used to predict the risk of tumor occurrence in 78 cases of people in Table 2, and...

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Abstract

The invention relates to a detection method used for predicting the occurrence risk of abnormal proliferation or tumors of the human body. The detection method comprises the following steps: 1) directly measuring the total mercapto content in a sample with dithio-bis-nitrobenzoic acid (DTNB); 2) using a specific thioredoxin reductase inhibitor compound to selectively inhibit the activity of thioredoxin reductase in the sample, and then, measuring the content of the other mercapto substances in the sample with DTNB, wherein the specific thioredoxin reductase inhibitor compound is the selen compound with TrxR inhibitory activity; and 3) subtracting the content of the other mercapto substances from the total mercapto content to obtain the content and activity of TrxR in the sample. The detection result in the invention can be used for predicting the occurrence risk of abnormal proliferation or tumors, and the method has specificity and high selectivity.

Description

technical field [0001] The invention belongs to the field of detection methods, and in particular relates to a detection method for predicting the risk of abnormal human proliferation or tumor occurrence. Background technique [0002] Under the stimulation of various factors, biological individuals make cell division active, the number of cells increases, and various diseases occur, which are called abnormal hyperplasia, such as compensatory hyperplasia, regenerative hyperplasia, endocrine hyperplasia, etc. Abnormal proliferation is closely related to tumorigenesis. Therefore, effective detection or prediction of abnormal proliferation is of great significance for predicting the risk of abnormal proliferation or tumor occurrence. However, there are no reports on the detection methods for predicting abnormal hyperplasia at home and abroad. Tumor markers used clinically at home and abroad are mainly used to detect antibody or protein levels after tumor formation, and cannot ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/26
CPCC07D345/00C12Q1/26G01N2333/90212
Inventor 曾慧慧
Owner KEAISE MEDICINE WUHAN
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