Antineoplastic podophyllum traditional Chinese medicine extract and preparation method and application thereof

An extract and anti-tumor technology, applied in the field of natural medicinal chemistry, achieves the effect of simple preparation method, low toxicity of normal cells, and good anti-tumor effect

Inactive Publication Date: 2011-07-27
JINAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report on the use of podophyllotoxins extracted from podophyllum traditional Chinese medicines in combination with flavonoids for anti-cancer

Method used

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  • Antineoplastic podophyllum traditional Chinese medicine extract and preparation method and application thereof
  • Antineoplastic podophyllum traditional Chinese medicine extract and preparation method and application thereof
  • Antineoplastic podophyllum traditional Chinese medicine extract and preparation method and application thereof

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Embodiment 1

[0076] (1) Preparation of podophyllotoxin and flavonoid extract for prevention and treatment of cancer

[0077] The original medicinal material of star anise lotus (rhizome part, 5.8kg) was dried, pulverized, passed through a 100-mesh sieve, and extracted by percolation with 95% (v / v) ethanol solution at room temperature for 3 times, each time for 1 hour, and filtered to obtain the total Extract: the total extract is concentrated under reduced pressure to dryness to obtain a total extract (680g), this total extract is suspended in water, extracted with ethyl acetate and n-butanol successively to obtain ethyl acetate extract respectively, and the normal Butanol extract, the remaining part is an aqueous solution; then these extracts are concentrated under reduced pressure to constant weight to obtain a slurry, which is ethyl acetate extract (508g), n-butanol extract (68g) and water Extract (104g).

[0078] (2) analyze the extract that step (1) obtains

[0079] Each extract tha...

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Abstract

The invention discloses an antineoplastic podophyllum traditional Chinese medicine extract and a preparation method and application thereof. The antineoplastic podophyllum traditional Chinese medicine extract contains a podophyllotoxin compound and a flavonoid compound. The preparation method comprises the following steps of: drying podophyllum plants, crushing, screening, extracting by using ethanol solution, and filtering to obtain total ethanol extract; and extracting the total ethanol extract by using ethyl acetate and n-butanol in turn to obtain ethyl acetate extract and n-butanol extract respectively, wherein concentrates of the total ethanol extract, the ethyl acetate extract and the n-butanol extract are the antineoplastic podophyllum traditional Chinese medicine extract. The invention proves that: the podophyllum traditional Chinese medicine extract which contains the podophyllotoxin compound and the flavonoid compound has a good antineoplastic effect, particularly on ethyl acetate extraction parts. The podophyllum traditional Chinese medicine extract has low toxicity to normal cells, is applied to the preparation of antineoplastic medicines, has high efficiency, and meets the requirements of medicine development.

Description

technical field [0001] The invention belongs to the field of natural medicinal chemistry, and in particular relates to an anti-tumor podophyllum traditional Chinese medicine extract and its preparation method and application. The anti-tumor podophyllum traditional Chinese medicine extract contains podophyllotoxins and flavonoids. Background technique [0002] Malignant tumor is a disease that seriously threatens human health, and its mortality rate is second only to cardiovascular disease. In recent years, with the aggravation of environmental pollution and changes in dietary structure, the incidence of cancer has been increasing year by year. According to the report of the World Health Organization, among the more than 6 billion people in the world, there are about 9 million new cancer patients every year, and about 7 million people die from cancer, accounting for about one-fifth of the total mortality. Although comprehensive methods such as surgery, chemotherapy, radioth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/29A61P35/00A61K31/365A61K31/7048
Inventor 江仁望李娟姜飞田海妍
Owner JINAN UNIVERSITY
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