Antineoplastic podophyllum traditional Chinese medicine extract and preparation method and application thereof

Abstract

The invention discloses an antineoplastic podophyllum traditional Chinese medicine extract and a preparation method and application thereof. The antineoplastic podophyllum traditional Chinese medicine extract contains a podophyllotoxin compound and a flavonoid compound. The preparation method comprises the following steps of: drying podophyllum plants, crushing, screening, extracting by using ethanol solution, and filtering to obtain total ethanol extract; and extracting the total ethanol extract by using ethyl acetate and n-butanol in turn to obtain ethyl acetate extract and n-butanol extract respectively, wherein concentrates of the total ethanol extract, the ethyl acetate extract and the n-butanol extract are the antineoplastic podophyllum traditional Chinese medicine extract. The invention proves that: the podophyllum traditional Chinese medicine extract which contains the podophyllotoxin compound and the flavonoid compound has a good antineoplastic effect, particularly on ethyl acetate extraction parts. The podophyllum traditional Chinese medicine extract has low toxicity to normal cells, is applied to the preparation of antineoplastic medicines, has high efficiency, and meets the requirements of medicine development.

Description

technical field [0001] The invention belongs to the field of natural medicinal chemistry, and in particular relates to an anti-tumor podophyllum traditional Chinese medicine extract and its preparation method and application. The anti-tumor podophyllum traditional Chinese medicine extract contains podophyllotoxins and flavonoids. Background technique [0002] Malignant tumor is a disease that seriously threatens human health, and its mortality rate is second only to cardiovascular disease. In recent years, with the aggravation of environmental pollution and changes in dietary structure, the incidence of cancer has been increasing year by year. According to the report of the World Health Organization, among the more than 6 billion people in the world, there are about 9 million new cancer patients every year, and about 7 million people die from cancer, accounting for about one-fifth of the total mortality. Although comprehensive methods such as surgery, chemotherapy, radioth...

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Problems solved by technology

At present, there is no report on the use of podophyllotoxins extracted from podophyllum traditional Chinese medicines in combination with flavonoids for anti-cancer

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