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Multi portion intra-oral dosage form and use thereof

A multi-part, oral technology, applied in pill delivery, pharmaceutical formulation, metabolic diseases, etc., can solve the problems of skin blood flow velocity, slow absorption of nicotine, irritation, etc.

Inactive Publication Date: 2011-09-14
MCNEIL AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The nicotine-containing skin patches widely used today cause local irritation, and the absorption of nicotine is slow and affected by the blood flow rate of the skin

Method used

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  • Multi portion intra-oral dosage form and use thereof
  • Multi portion intra-oral dosage form and use thereof
  • Multi portion intra-oral dosage form and use thereof

Examples

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Embodiment Construction

[0032] definition

[0033] The following definitions apply mutatis mutandis to expressions similar to those defined below.

[0034] The term "sensory sensation" is intended herein to denote characteristics of the embodiments that can be discerned by a subject's taste, mouthfeel, smell, hearing and / or vision, such as (but not limited to) flavor, cooling, burning, warming , stinging, bubbling, effervescent, effervescent, hot, mouth-watering, crunchy, sticky, physical form, texture (e.g. firm, soft, rough) and imprint.

[0035] The term "nicotine-mimicking component" is intended herein to mean a component, whether in the form of nicotine or not, which in some respects can be considered to possess or resemble any organoleptic characteristic of nicotine.

[0036] The term "intraoral dosage form" is intended herein to mean a dosage form intended to be administered into the systemic blood circulation by means of absorption of the active ingredient (ie, pharmaceutically active comp...

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PUM

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Abstract

The present invention relates to a multi portion intra-oral dosage form where at least one portion is rapidly disintegrating and at least one portion is slowly disintegrating, whereby the disintegration time for the slowest disintegrating portion is at least two times longer than for the most rapidly disintegrating portion. Of certain interest is use of sensory markers / signals as conceptual aids for the subject.,Also contemplated are a method and a system for delivering active agents, such as,nicotine and / or metabolites thereof, such as cotinine, nicotine N'-oxide, nornicotine, (S)-nicotine-N-ss-glucuronide and mixtures, isomers, salts and complexes thereof as well as use and production of said formulations.

Description

technical field [0001] The present invention relates to a multi-part intraoral dosage form wherein at least one part disintegrates rapidly and at least one part disintegrates slowly, whereby the disintegration time of the slowest disintegrating part is at least twice the disintegration time of the fastest disintegrating part . Of concern is the use of sensory markers / signals as conceptual aids for subjects. [0002] Also contemplated are methods and systems for the delivery of active agents such as nicotine and / or metabolites thereof, such as cotinine, nicotine N'-oxide, normethyl Nicotine, (S)-nicotine-N-beta-glucuronide and mixtures, isomers, salts and complexes thereof. Background technique [0003] Tobacco dependence and its reduction are desirable goals. In recent years, with awareness of the harmful effects of tobacco smoking, many campaigns and projects have been launched by government ministries and various health groups and other relevant organizations to dissemi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/24A61P25/34
CPCA61K9/0056A61K9/209A61K9/4808A61P1/02A61P1/12A61P3/00A61P11/06A61P11/14A61P25/00A61P25/26A61P25/34A61P27/00A61P43/00A61K9/20
Inventor K·林德尔K·西瑞森F·尼科拉森F·布尼克J·卢伯A·胡格斯
Owner MCNEIL AB
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