eye drops
A technology of eye drops and hydroxyethyl cellulose, which is applied in the field of tear film stabilizers, ocular surface retention accelerators for eye drops, and eye drops containing thickeners for ophthalmology, and can solve the problem of uncombined hydroxyethyl cellulose Eliminate dryness or discomfort, increase retention, and improve dry eye symptoms
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[0045] Hereinafter, examples are given to illustrate the present invention in detail, but these examples are only for better understanding of the present invention, and cannot limit the scope of the present invention.
[0046] Viscosity measurement test in coexistence with mucin
[0047] This test is based on the test method described in Pharmaceutical Research, 491-495, Vol.7, No.5, 1990, by measuring the viscosity of each test solution when it coexists with the mucin solution, and evaluating the contact of each test solution with the mucin solution. synergistic thickening effect.
[0048] (experimental method)
[0049] As shown in Table 1, physiological saline was prepared and each thickener was dissolved in the physiological saline to obtain test solutions 1-6. Separately, mucin (manufactured by SIGMA) was dissolved in 0.1 M phosphate buffer so that the pH was the same as that of tear fluid (neutral) to prepare a 4% mucin solution (pH 7.0).
[0050] [Table 1]
[0051] ...
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