eye drops

A technology of eye drops and hydroxyethyl cellulose, which is applied in the field of tear film stabilizers, ocular surface retention accelerators for eye drops, and eye drops containing thickeners for ophthalmology, and can solve the problem of uncombined hydroxyethyl cellulose Eliminate dryness or discomfort, increase retention, and improve dry eye symptoms

Inactive Publication Date: 2011-12-14
SANTEN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] But none of the above-mentioned documents combine hydroxyethyl cellulose and dextran

Method used

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Examples

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Embodiment Construction

[0045] Hereinafter, examples are given to illustrate the present invention in detail, but these examples are only for better understanding of the present invention, and cannot limit the scope of the present invention.

[0046] Viscosity measurement test in coexistence with mucin

[0047] This test is based on the test method described in Pharmaceutical Research, 491-495, Vol.7, No.5, 1990, by measuring the viscosity of each test solution when it coexists with the mucin solution, and evaluating the contact of each test solution with the mucin solution. synergistic thickening effect.

[0048] (experimental method)

[0049] As shown in Table 1, physiological saline was prepared and each thickener was dissolved in the physiological saline to obtain test solutions 1-6. Separately, mucin (manufactured by SIGMA) was dissolved in 0.1 M phosphate buffer so that the pH was the same as that of tear fluid (neutral) to prepare a 4% mucin solution (pH 7.0).

[0050] [Table 1]

[0051] ...

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Abstract

The object of the present invention is to provide a kind of eye drop, the hydroxyethyl cellulose containing 0.001~10% (w / v) and the dextran of 0.001~10% (w / v), the pH of described eye drop 4 to 8, characterized in that the viscosity is increased by contact with the mucin of the tear film during eye drops. The present invention also provides an eye drop containing 0.01-5% (w / v) hydroxyethyl cellulose and 0.005-3% (w / v) dextran, the pH of the eye drop being 4 ~8, characterized in that the viscosity is increased by contact with the mucin of the tear film during eye drops.

Description

[0001] This application is a divisional application of the application dated May 27, 2005, application number 200580016815.8 (international application number PCT / JP2005 / 009727), and invention name "thickener for ophthalmology". technical field [0002] The invention relates to an ophthalmic thickener composed of hydroxyethyl cellulose and dextran. In addition, the present invention relates to an eye drop containing a thickener for ophthalmology, wherein the thickener is a combination of hydroxyethyl cellulose and dextran, and is characterized in that it passes through the adhesion with the tear film during eye drops. Protein contact increases viscosity. In addition, the present invention also relates to a tear film stabilizer and ocular surface retention accelerator for eye drops composed of hydroxyethyl cellulose and dextran. Background technique [0003] When the viscosity of the eye drops is high, it stays on the surface of the eye for a long time, and can continue to e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/38A61K47/36A61P27/02A61K9/00
CPCA61K9/0048A61P27/02A61K47/36A61K9/08A61K47/38
Inventor 坂本佳代子木村章男平井慎一郎中村雅胤
Owner SANTEN PHARMA CO LTD
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