Time-temperature color-changing indicator and application and using method thereof

A technology of temperature indicator and indicator, applied in the field of transportation

Active Publication Date: 2012-02-01
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are few relevant reports on time-temperature indicators in China, but in the distribution chain of perishable products from factories

Method used

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  • Time-temperature color-changing indicator and application and using method thereof
  • Time-temperature color-changing indicator and application and using method thereof
  • Time-temperature color-changing indicator and application and using method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0159] Example 1 Monitoring of items stored at 40°C for 1 hour

[0160] 1. Preparation and characterization of PDA vesicles

[0161] Dissolve 40 mg PCDA in CH 2 Cl 2 , and then evaporate the solvent to dryness, add 20 ml of water, and sonicate for 10 minutes at a temperature of 75°C. Then lower the temperature and store overnight at 4°C to crystallize the lipid film. The polymerization reaction was carried out in an ice bath for 5 minutes under the irradiation of ultraviolet light with a wavelength of 254 nm. Finally, the obtained PDA vesicles were stored at 4°C for future use. The average particle size of PDA vesicles is 128.5±4.8nm by laser particle size analyzer. Results are the average of three tests.

[0162] 2. Preparation of F127 aqueous solution

[0163] An aqueous solution of F127 with a concentration of 0.5 wt% was prepared. The molecular structure of F127 is PEG99-PPG67-PEG99, and the molecular weight is 12700.

[0164] 3. Use PDA vesicles / F127 to monitor i...

Embodiment 2

[0166] Example 2 Monitoring of items stored at 20°C for 4 hours

[0167] The preparation concentration of F127 in Example 1 was changed to 15 wt%, and HCDA was used instead of PCDA to prepare PDA vesicles, and other steps were the same as in Example 1.

[0168]When the items to be monitored are shipped, mix PDA vesicles with F127 at a concentration of 15%, put the mixture together with the items to be transported, and ship; when arriving at the end of the transport chain, if a certain PDA vesicle / F127 is found When the color of the mixture changes, that is, from blue to red, it means that the set storage temperature and time have been exceeded, and it cannot be eaten or used.

Embodiment 3

[0169] Embodiment 3 monitoring storage condition is 2 days under the temperature of 20 degrees

[0170] In Example 1, PDDA was used instead of PCDA to prepare PDA vesicles, and Tween-20 was used instead of F127 to prepare a Tween-20 solution with a concentration of 15 wt%. The other steps were the same as in Example 1.

[0171] PDA / Tween-20 (concentration is 15wt%) is used to monitor the article that storage condition is 2 days under the temperature of 20 degrees: when the article to be monitored is dispatched, the Tween-20 that PDA vesicle is mixed with concentration of 15%, will The mixture and the items to be transported are put together for delivery. In order to ensure the accuracy, multiple sets of mixtures can be placed at the same time; when the end of the transportation chain is reached, if the color of a certain PDA vesicle / Tween-20 mixture is found to change, it will be changed by blue When the color turns red, it means that the set storage temperature and time have ...

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Abstract

The invention relates to a time-temperature color-changing indicator and application and a using method thereof, belonging to the technical fields of monitoring of vaccine and medicament storage. The time-temperature color-changing indicator comprises a polydiacetylene (PDA) vesicle and an amphiphilic polymer aqueous solution, wherein the PDA vesicle is formed by polymerizing a diacetylene substance shown as a formula I after self-assembly, and is shown as a formula II; and in the formula II, R refers to a hydrophilic group, and R' refers to a chain segment of a hydrophobic group. The time-temperature color-changing indicator is used for monitoring temperature change and time change within the temperature range of 0-50 DEG C, such as time and temperature changes and the like during monitoring of vaccine and bio-medicament transportation. The time-temperature color-changing indicator is convenient to use, is simple and effective, and is an indicator with practical application prospect.

Description

technical field [0001] The invention relates to a time-temperature color-changing indicator, in particular to a polydiacetylene-based time-temperature color-changing indicator, which belongs to the technical field of monitoring the transportation of food, vaccines and the like. Background technique [0002] The quality of food and other perishable products (such as fresh food products, vaccines, certain pharmaceuticals, etc.) is highly dependent on storage and transport conditions, such as temperature and Conditions such as storage time, as the temperature increases and the time becomes longer, the deterioration process is accelerated due to the increase in the rate of biochemical reactions; therefore, these products need to be stored under conditions that do not exceed specific temperature limits during transportation, Or at least the storage time cannot exceed the predetermined time interval. [0003] Currently, only date markings are generally used to assure storage qual...

Claims

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Application Information

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IPC IPC(8): C08L49/00C08L71/00C08L39/06C08F138/00G01K11/16G01N21/31G01N21/78
Inventor 钱志勇魏于全苟马玲赵霞
Owner SICHUAN UNIV
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