Hydroxyphenylalanine urine detection reagent and preparation method thereof

Abstract

The invention relates to an external detection reagent for clinic diagnosis, particularly to a hydroxyphenylalanine urine detection reagent which is a determination reagent for metabolic disorder in the body and its preparation method. The urine detection reagent is prepared by respectively dissolving Hg2<+>, Hg<2+>, Ni<2+> and Cd<2+> in corresponding acid solutions and mixing in proportion. The mercuric sulfate as a donor of Hg<2+> is dissolved in a sulfuric acid solution, the mercurous nitrate as a donor of Hg2<+> is dissolved in a nitric acid solution, the nickel sulfate as a donor of Ni<2+> is dissolved in distilled water, and the cadmium sulfate as a donor of Cd<2+> is dissolved in a nitric acid solution. The invention overcomes the defects and disadvantages existing in the prior art, and the detection reagent is a urine analysis reagent for metabolic disorder with novel formula and has high stability, sensitivity and wide application range.

Description

technical field [0001] The invention relates to an in vitro detection reagent for clinical diagnosis, in particular to a reagent for judging abnormal metabolism in the human body—a urine detection reagent for p-hydroxyphenylalanine and a preparation method thereof. Background technique [0002] Major metabolic diseases such as malignant tumors and diabetes caused by abnormal cell metabolism in the body have attracted more and more attention. The key to treating diseases caused by abnormal metabolism in the body lies in early detection, early diagnosis and early treatment. At present, the resulting disease diagnosis methods mainly include physics, histocytology and biochemistry. For tumor diseases, physics and histocytology often can only detect the middle and late stages, and it is difficult to achieve the purpose of early detection, and most of the operations are complicated and expensive. Early diagnosis of metabolic diseases such as malignant tumors is the most critica...

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Problems solved by technology

The reagents provided by the above-mentioned prior art have certain effects in application, high specificity and sensitivity, but there are still deficiencies. The reagents provided by Chinese patent CN1096374 have a high false positive rate, greater than 10%, and are not applicable Due to the general screening of tumors, the number of EP341803 specimens tested is small, so the reliability of the statistical results is not strong

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