Fully automatic intelligent infusion method and device based on model predictive control for large doses of insulin

Abstract

The invention provides an intelligent method based on model predictive control for automatic infusion of large doses of insulin, which is characterized in that: a continuous glucose monitoring system (CGMS) and an insulin pump are used as the basis of hardware; online detection of food is carried out based on a strong tracking filter; when the food is detected, large doses of insulin is transfused immediately, and the amount of insulin depends on historical food; whether the dosage is needed to be increased is judged every 30 minutes based on the model predictive control, and the dosage is designed; when the blood glucose concentration decreases, whether the basic amount of insulin is needed to be maintained is determined according to the predicted blood glucose value; and finally the blood glucose concentration is controlled to be within the safe range. Compared with the existing corresponding technology, the invention has the advantages of high degree of intelligence and fully automatic operation, and the blood glucose control effects can be improved significantly in case that self-management cannot be carried out by patients.

Description

technical field [0001] The invention relates to an intelligent method for automatically designing large doses of insulin, in particular to an intelligent design method based on model predictive control, which belongs to the field of biomedical engineering. Background technique [0002] With the improvement of material living standards and the deterioration of the environment, diabetes has increasingly become an important disease that seriously endangers human health. Diabetes is the leading cause of blindness, kidney failure, and lower limb amputation, as well as death from cardiovascular complications. Diabetes is the fourth leading cause of death in humans, and the number of deaths caused by diabetes accounts for 6.8% of the total number of deaths. Nearly 4 million people die from diabetes and its complications every year. 11.6% of global healthcare spending is spent on treating diabetes and its complications each year. [0003] The main cause of complications is hypergl...

AI Technical Summary

Problems solved by technology

[0006] However, the large doses of all current insulin pumps require the participation of patients in the design, which brings great inconvenience to the lives of them and their families

In particular, many people with type 1 diabetes are children and adolescents, and it is often not practical for them to input dietary information into the insulin pump before each meal

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