Diclofenac diethylamine emulgel and preparation method thereof

Abstract

The invention discloses diclofenac diethylamine emulgel. In the emulgel, isopropyl myristate, isopropyl alcohol and propylene glycol are combined as a penetration enhancer; carbomer 980 is used as a water-based gel substrate matrix; liquid paraffin is used as an oil-phase matrix; and polysorbate 80 and glycerol monostearate / distearate are used as emulsifiers. The diclofenac diethylamine emulgel disclosed by the invention is high in in-vitro penetration absorption speed, takes effect quickly, and is favorable for easing the pain of a patient in time; and moreover, the diclofenac diethylamine emulgel has the characteristics of less skin irritation and high stability.

Description

technical field

[0001] The invention relates to a diclofenac diethylamine emulsion and a preparation method thereof. Background technique

[0002] Diclofenac diethylamine is a non-steroidal anti-inflammatory analgesic, which has anti-inflammatory and analgesic effects. When applied topically, its active ingredients can penetrate the skin to reach the inflammatory area, relieve acute and chronic inflammatory reactions, and reduce inflammatory swelling , Pain relief. Diclofenac diethylamine gels and emulsions have been marketed in China. However, due to the strong hydrophilicity of diclofenac diethylamine, common topical preparations have poor skin penetration, slow drug onset, and unsatisfactory bioavailability. The use of emulsification technology in preparation technology can increase the fat solubility of diclofenac diethylamine to a certain extent. For example, the diclofenac diethylamine emulsion (trade name: Voltaren latex) currently on the market in China uses isoprop...

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