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New application of alpinetin

A technology of alginol and new use, applied in the field of medicine, can solve problems such as medicine or health food for ulcerative colitis without alginol, and achieve the effects of improving weight loss and significant therapeutic effect

Inactive Publication Date: 2012-10-03
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no relevant report that alpinol can be used as an active ingredient i

Method used

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  • New application of alpinetin
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  • New application of alpinetin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0022] 1. Experimental materials

[0023] 1.1 Medicinal materials

[0024] Alpinol (CAS: 36052-37-6 molecular weight 270.28, HPLC purity ≥ 98%, Chengdu Master Biotechnology Co., Ltd.); dextran sodium sulfate (DSS, CAS: 9011-18-1, molecular weight 35000 ~ 44000 , produced by MPBiomedical LLC); Sulfasalazine (SASP, CAS: 599-79-1, molecular weight 398.39, HPLC purity ≥ 98%, produced by Sigma).

[0025] 1.2 Experimental animals

[0026] C57BL / 6 mice (8-10 weeks) weighing 20±2g were provided by the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine, animal certificate number: SYXK (Shanghai) 2009-0069. Placed in a conventional feeding environment, free access to food and water.

[0027] 2. Experimental method

[0028] 2.1 Establishment of ulcerative colitis model

[0029] Adding dextran sodium sulfate (Dextran sulfate sodium, DSS) to the drinking water directly to the animals to drink freely will cause the destruction of the tissue structure of t...

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PUM

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Abstract

The invention discloses new application of alpinetin. The new application means that the alpinetin serving as an active ingredient is used for preparing medicaments or health-care food for treating ulcerative colitis. Experimental results show that the alpinetin can obviously improve the symptoms such as weight loss, bloody stool, colon shortening, inflammatory cell infiltration and pathological tissue damage of ulcerative colitis mice, and can inhibit the expression of proinflammatory factors TNF-alpha and IL-6. Therefore, the alpinetin serving as the active ingredient is expected to be developed into a medicament or health-care food for treating the ulcerative colitis. The medicinal value of the alpinetin can be fully exerted, and the invention has significance for research and application of the alpinetin.

Description

technical field [0001] The invention relates to a new application of alpinol, in particular, relates to the application of alpinol in the preparation of medicine or health food for treating ulcerative colitis, and belongs to the technical field of medicine. Background technique [0002] Ulcerative colitis (UC) belongs to inflammatory bowel disease (Inflammatory bowel disease, IBD). Environmental, microbial and other factors are closely related. The clinical manifestations are mainly diarrhea, abdominal pain, mucus pus and blood in the stool and recurrent attacks. Colonoscopy showed mucosal hyperemia, edema, erosion, bleeding and ulcers. Foreign epidemiological data show that the disease can occur at any age, and it is more common in young adults aged 20-40. In recent years, with the improvement of living standards and changes in diet structure and lifestyle, the incidence rate in my country has been increasing year by year. The disease has a long course and recurrent att...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P1/04A23L1/29A23L33/00
Inventor 窦薇王峥涛张晶晶杨莉丁丽丽
Owner SHANGHAI UNIV OF T C M
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