Pharmaceutical composition, and preparation method and application thereof

A technology of composition and drug, applied in antibacterial drugs, glycopeptide components, organic chemistry, etc.

CN106674249AInactive Publication Date: 2017-05-17XIANGTAN ZHILIAN TECH MATASTASIS PROMOTE CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2017-05-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a pharmaceutical composition and application thereof. The pharmaceutical composition contains compounds disclosed as chemical formula (I) or pharmaceutically acceptable salts and a pharmaceutically acceptable carrier. The pharmaceutical composition disclosed by the invention can be used for preparing antibacterial drugs, and especially preparing drugs for preventing or treating vancomycin-resistant bacterial infection diseases. The experimental data indicates that the compounds can effectively inhibit growth of vancomycin-resistant enterococcus when being combined with glycopeptide antibacterial drugs.
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Description

technical field

[0001] The invention relates to a pharmaceutical composition, its preparation method and application, in particular to a pharmaceutical composition, its preparation method and its application on vancomycin-resistant bacteria, and belongs to the field of medicinal chemistry. Background technique

[0002] Bacteria (Bacteria) is one of the main groups of organisms, belongs to the domain of bacteria, and is the most numerous type of all organisms. Bacteria are both useful and harmful to the environment, humans and animals. Some bacteria become pathogens, causing various infectious diseases such as tetanus, typhoid, pneumonia, syphilis, cholera, and tuberculosis. In plants, the bacteria cause leaf spot, fire blight and wilting.

[0003] In the 1950s and 1960s, known as the "golden age" of antibiotics, about 7 million people died of infectious diseases worldwide every year, and this number rose to 20 million by 1999. In the United States, known as the most techno...

Examples

Embodiment 1

[0059] Reaction a prepares compound (formula IA), reacts as follows:

[0060]

[0061] After testing, the compound (formula IA) molecular formula is C 11 h 11 FN 2 o 3 S; After testing, the compound (formula IA) obtained in this example is the compound (formula I) provided by the present invention:

[0062]

Embodiment 2

[0064] Reaction b prepares compound (formula IA'), reaction is as follows:

[0065]

[0066] After testing, the molecular formula of the compound (formula IA') obtained in this example is C 11 h 11 ClN 2 o 3 S; Through testing and embodiment 1 is

[0067] The same compound, that is, formula IA and formula IA' are compounds provided by the present invention (formula I):

[0068]