Indiplon orally disintegrating tablet and preparation method thereof

A technology of orally disintegrating tablets and indiplon, which is applied in pill delivery, nervous system diseases, drug combination, etc., can solve problems such as long production cycle, high cost, and complicated operation

Inactive Publication Date: 2012-12-26
BEIJING D VENTUREPHARM TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, domestic patents on orally disintegrating tablets of sedative-hypnotics and patents on indiplon preparations are few, among which CN1025521292A discloses a kind of orally-disintegrating tablets of sedative-hypnotics and its preparation method, the invention adopts freeze-drying method The preparation of orally disintegrating tablets is complex in operation, long in production cycle, and high in cost. This method is widely used in foreign countries. Due to the limitation of equipment, this method is generally not used in the preparation of orally disintegrating tablets in China.

Method used

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  • Indiplon orally disintegrating tablet and preparation method thereof
  • Indiplon orally disintegrating tablet and preparation method thereof
  • Indiplon orally disintegrating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of embodiment 1 indiplon orally disintegrating tablet (5mg)

[0029]

[0030] Preparation Process:

[0031] (1) Pulverizing the indiplon raw material through a 100-mesh sieve;

[0032] (2) The pulverized raw material and the prescribed amount of mannitol, microcrystalline cellulose, crospovidone, croscarmellose sodium, and acesulfame potassium are mixed in equal amounts;

[0033] (3) Add silicon dioxide and magnesium stearate to the above mixture, mix well and press into tablets with a tablet weight of 100mg and a hardness of 30-40N

Embodiment 2

[0034] Embodiment 2 Preparation of indiplon orally disintegrating tablet (10mg)

[0035]

[0036] Preparation Process:

[0037] (1) Pulverizing the indiplon raw material through a 100-mesh sieve;

[0038] (2) The pulverized raw material and the prescribed amount of mannitol, microcrystalline cellulose, crospovidone, croscarmellose sodium, and acesulfame potassium are mixed in equal amounts;

[0039] (3) Add silicon dioxide and magnesium stearate to the above mixture, mix well and press into tablets with a tablet weight of 100mg and a hardness of 30-40N

Embodiment 3

[0040] The preparation of embodiment 3 indiplon orally disintegrating tablet (5mg)

[0041]

[0042] Preparation Process:

[0043] (1) Pulverizing the indiplon raw material through a 100-mesh sieve;

[0044] (2) The pulverized raw material and the prescription amount of wood dew alcohol, microcrystalline cellulose, crospovidone, croscarmellose sodium, and acesulfame potassium are mixed in equal amounts;

[0045] (3) Add silicon dioxide and magnesium stearate to the above mixture, mix well and press into tablets with a tablet weight of 100mg and a hardness of 30-40N

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Abstract

The invention belongs to the medical field of medicine, and particularly discloses an indiplon orally disintegrating tablet, which has a good taste, dispenses with water when being taken, can be rapidly disintegrated after entering the mouth, is suitable for being taken by dysphagia patients such as the old people and children and is also suitable for being taken under the condition that water sources are difficult to obtain, such as during a journey or wartime. The indiplon orally disintegrating tablet is sedative-hypnotic taken before bedtime, dispenses with the water when being taken, can prevent the phenomenon that the sleep quality is influenced by micturition desire after the medicine is taken by using water before the bedtime, and has good medicine taking compliance. The invention also discloses a preparation method of the indiplon orally disintegrating tablet, which has the advantages that a process is simple, the cost is low, the prepared orally disintegrating tablet is disintegrated fast and acts rapidly, and the medicine taking discomfort of a patient is reduced.

Description

technical field [0001] The invention relates to a sedative-hypnotics orally disintegrating tablet and a preparation method thereof, in particular to an indiplon orally disintegrating tablet and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] In recent years, due to the increasing number of patients with insomnia and depression, the market of sedative and hypnotics has become increasingly hot. In 2005, the global market size of insomnia treatment drugs reached 3.8 billion US dollars, and in 2006 it reached 6.1 billion US dollars. It is expected that by 2016, this market size will grow to 7.7 billion US dollars. The term "insomnia" is used to describe all uncomfortable symptoms that resemble a patient's sleep deprivation or non-restful sleep perception. Insomnia may come from a variety of different or even co-existing causes. As the pace of society accelerates and competition intensifies, insomnia has become a very com...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/519A61P25/20
Inventor马莉郭夏宋雪梅
OwnerBEIJING D VENTUREPHARM TECH DEV