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Novel application of patchouli alcohol

A technology of patchouli alcohol and uses, applied in the directions of active ingredients of hydroxyl compounds, antiviral agents, etc., to achieve the effect of low toxicity and side effects

Inactive Publication Date: 2015-04-15
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Since the 1990s, researchers have discovered many new antiviral drugs. At present, there are more than 20 antiviral drugs in clinical use, but their exact efficacy is still controversial.
[0008] At present, there are no related reports on the use of patchouli alcohol to resist adenovirus and treat adenovirus infectious diseases

Method used

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  • Novel application of patchouli alcohol
  • Novel application of patchouli alcohol
  • Novel application of patchouli alcohol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of embodiment 1 antiviral preparation

[0023] Take patchouli alcohol, add appropriate amount of soluble starch and dextrin, and granulate to obtain the antiviral granule of the present invention.

Embodiment 2

[0024] Example 2 Anti-adenovirus effect of patchouli alcohol

[0025] 1. Materials and instruments

[0026] 1.1 Cell strains and virus strains

[0027] 1.1.1 Cell lines:

[0028] Hep-2 cells (human laryngeal carcinoma epithelial cells) were purchased from China National Institute for the Control of Pharmaceutical and Biological Products.

[0029] 1.1.2 Virus strains:

[0030] The adenovirus is the common human adenovirus type 3 (HAdv-3), which is a clinical isolate donated by the Gansu Provincial Center for Disease Control and Prevention.

[0031] 1.2 Drugs and control drugs

[0032] Test drug: patchouli alcohol.

[0033] Positive drug: Acyclovir for injection: the specification is 0.25g / bottle, produced by Tianjin Pharmaceutical Jiaozuo Co., Ltd.

[0034] Approval number: Guoyao Zhunzi H20034034, production batch number: 10122403.

[0035] 1.3 Media, reagents and consumables

[0036] DMEM medium (Gibco TM company, batch number 1345538); fetal bovine serum (HyClone Bi...

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Abstract

The invention discloses an application of patchouli alcohol to preparation of a medicament for resisting adenoviruses. Patchouli alcohol can be used for effectively inhibiting the synthesis of type 3 adenoviruses, has a certain adenovirus resisting function, and can be used for treating adenovirus infectious diseases, particularly human type 3 adenovirus infectious diseases; and meanwhile, the toxicity of patchouli alcohol on host cells is far lower than that of a positive medicament, i.e., acyclovir, the toxic and side effects of the patchouli alcohol are reduced, and a novel safe and effective option is provided for clinical administration.

Description

technical field [0001] The present invention relates to the new application of patchouli alcohol. Background technique [0002] Adenovirus AdV (Adneovirus) is a non-enveloped double-stranded DNA virus wrapped by an icosahedral protein shell. Adenoviruses primarily infect a variety of vertebrates, including humans. Among them, the human adenovirus (Human adenovirus, HAdv) belongs to the mammalian adenovirus genus. There are 56 types of HAdv discovered so far, which are divided into 7 species (A-G). Among them, the B type adenovirus is closely related to human pathogenicity, especially the human adenovirus type 3 (also known as human adenovirus) among the B type adenoviruses. The source adenovirus type 3, HAdv-3) has higher virulence and is associated with severe clinical symptoms (Zhang Qiwei, et al., Isolation and identification of human adenovirus type 3 GZ13 strain and molecular evolution of hexon protein). [0003] At present, it has been found that adenovirus is a com...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/045A61P31/20
Inventor 彭成魏晓露熊亮万峰
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE