Preparation method and biological application of t1-t1 synergistic gadolinium chelated manganese tetraoxide nanoparticles

A nano-manganese tetraoxide, T1-T1 technology, applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agents, etc., can solve the problems of nanoparticle research methods that have not been seen, and achieve low price, uniform particle size, and easy availability of raw materials Effect

Active Publication Date: 2014-10-29
SHANGHAI NORMAL UNIVERSITY
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Problems solved by technology

[0007] After extensive retrieval of domestic and foreign patent documents and publications, there is no nanoparticle research method with the same synergistic effect as the present invention

Method used

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  • Preparation method and biological application of t1-t1 synergistic gadolinium chelated manganese tetraoxide nanoparticles
  • Preparation method and biological application of t1-t1 synergistic gadolinium chelated manganese tetraoxide nanoparticles
  • Preparation method and biological application of t1-t1 synergistic gadolinium chelated manganese tetraoxide nanoparticles

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Embodiment Construction

[0037] The preparation method of the manganese tetraoxide nanoparticles chelated with manganese gadolinium comprises the following steps:

[0038] (1) Preparation of manganese acetylacetonate precursor:

[0039] Take 2.5 g of MnCl 2 4H 2Dissolve O in 15 mL of water; add 5.0 mL of acetylacetone to the above solution; stir at room temperature for 30 min; add 5.0 mL of triethylamine; extract the yellow precipitate from the reaction solution and filter it;

[0040] Prepare a mixed solution of ethanol and water with a volume ratio of 4:1, add the yellow solid obtained by extraction and filtration to the mixed solution of ethanol and water, heat to 75-80°C, stir until completely dissolved and the solution becomes a brown transparent liquid; cool at room temperature , filter the yellow needle-like crystals in the solution to obtain the acetylacetonate manganese precursor;

[0041] (2) Preparation of surface oleylamine coordinated oil-soluble manganese tetraoxide nanoparticles seed...

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Abstract

The invention discloses a preparation method and biological application of T1-T1 synergistic effect gadolinium chelate manganous-manganic oxide nano particles. The preparation method and the biological application of the T1-T1 synergistic effect gadolinium chelate manganous-manganic oxide nano particles include that firstly manganeseacetylacetonate is combined, and then oleylamine is used as a solvent, a high-temperature pyrolysis method is used to combine oil solubility manganous-manganic oxide nano particles, and then a ligand exchange method is utilized to use alendronate to be exchanged on the surfaces of the manganous-manganic oxide nano particles, so that nano particles are formed, wherein the surfaces of the nano particles are provided with a large number of amino groups. Then, the surfaces of the amino groups are connected with diethylenetriamine pentaacetic acid, so that the surfaces of the nano particles are provided with a large number of carboxyl groups, and at last a chelate effect is utilized to enable the large number of carboxyl groups and gadolinium to be chelated. Therefore, gadolinium chelate manganous-manganic oxide nano particles are obtained. The preparation method is low in requirement for equipment, convenient for operated process, low in needed raw material cost, and nuisanceless in accessory products. And at last through in vitro and in vivo magnetic resonance imaging experimental testing, so that compared with independent manganese and independent gadolinium, T1 magnetic resonance imaging contrast effect is strengthened.

Description

technical field [0001] The invention belongs to the technical field of contrast agents, and relates to a method for preparing an enhanced image contrast agent and its biological application, in particular to a T 1 -T 1 Preparation method and biological application of synergistic gadolinium chelated manganese tetraoxide nanoparticles. Background technique [0002] Since the birth of CT, imaging medicine has gone through a period of rapid development for 40 years. Today, we have imaging equipment with extremely powerful performance: 320-slice CT, 7T magnetic resonance, PET-CT, the display capability limit of an imaging equipment is determined by its principle. CT, which uses X-rays plus rotational acquisition for imaging. Imaging times are on the sub-second level. During the rotation process, the slip ring will inevitably shake, the X-ray intensity is constantly fluctuating, and the human blood and organs are in motion. All these determine that its spatial resolution can o...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06
Inventor 杨仕平汪娟娟周治国陈冬梅杨昕仪孔斌
Owner SHANGHAI NORMAL UNIVERSITY
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