Preparation technology of Anshenbao particle extractive

A preparation process and extract technology are applied in the field of preparation process of Anshenbao granule extract, which can solve the problems of many ineffective components of extract and large amount of extract, reduce the amount of prepared extract, reduce dosage, and improve labor productivity Effect

Inactive Publication Date: 2013-02-27
HEBEI YUZHILIN PHARMA
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention aims to solve the problems of large amount of extract and too many ineffective ingredients in the extract, and provides a preparation process of Anshenbao granule extract that selectively removes impurities and retains active ingredients to the greatest extent

Method used

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Embodiment Construction

[0013] A preparation process of Anshenbao granule extract, including preparation of materials in proportion, preparation of extract solution, refining extraction process, and drying process. The key is: the refining extraction process includes the steps of preparing refined solution and preparing extract,

[0014] Among them, the method for preparing the refined solution is: centrifuge the extract in a high-speed centrifuge, the maximum speed of the centrifuge is 20000-25000rpm, the maximum relative centrifugal force is 89000×g, the solid-liquid is separated by sedimentation, and the centrifuged solution is collected to obtain the refined solution; or The extract is adsorbed, removed, and purified by a macroporous resin column, eluted with 60% ethanol, and the elution flow rate is controlled at 3-5ml / min, and the eluate is collected to obtain a refined solution; or the extract is passed through an ultrafiltration membrane. Filtration, the ultrafiltration membrane rated pore siz...

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Abstract

The invention provides a preparation technology of Anshenbao particle extractive, aiming at solving the problem that the existing preparation technology is large in prepared extract quantity and excessive in the inactive substances in the extract. When the refined liquid and the extractive are prepared in the preparation technology, the extracting solution is refined, purified and purified due to the screening of the macroporous resin or the ultrafiltration membrane, so that the prepared extract quantity can be reduced, the labor productivity can be improved, and the each-time extract dose can be reduced. Meanwhile, the drying treatment is carried out on the extracted refined liquid by pressure-reduced drying or spray drying, so that the integrity and the quantity of the active ingredients can be furthest remained, and the bioavailability of the medicine can be improved.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and relates to a preparation process of Anshenbao granule extract, in particular to a preparation process of Anshenbao granule extract which can solve the problem of excessive ineffective components in extracts. Background technique [0002] At present, Anshenbao granules are generally prepared by concentrating the leachate into an extract, adding sucrose powder 6 times the weight of the extract to make wet granules, and then drying them. This process requires a large amount of sucrose, resulting in a large dosage of granules. , it is inconvenient to use, and the high sugar content is not suitable for some sugar-free patients. This method is difficult to granulate, and the granule forming rate is about 70%, which is relatively low, which leads to low labor productivity. Anshenbao Granules Manufacturing costs remain high. And there are too many invalid ingredients in the extract, whi...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/815A61P25/20
Inventor张赞卿龙
OwnerHEBEI YUZHILIN PHARMA