Preparation method of kidney tonifying and abdominal mass eliminating granule extract treating endometriosis

An endometrial and extract technology, which is applied in the field of drug preparation, can solve the problems of large dosage and too many ineffective ingredients in decoction, and achieve the effects of small dosage, improving bioavailability and reducing dosage.

Inactive Publication Date: 2018-10-09
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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Problems solved by technology

[0004] The technical problem to be solved in the present invention is to provide a preparation method of Yishen Xiaozheng granule extract for the treatment of endometriosis. The extract prepared by the preparation method solves the problem of the large dosage of traditional decoctions and the problems in decoctions. Technical problems with too many ineffective ingredients

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Embodiment Construction

[0087] This embodiment provides a method for preparing the extract of Yishen Xiaozheng Granules, which includes preparing materials in proportion, preparing extraction liquid, refining extraction process, and drying process. The key is: the refining extraction process includes preparing refined liquid and preparing extraction object step.

[0088] The method for preparing the refined liquid is:

[0089] The preparation method of the alcohol extraction refined liquid is as follows: the alcohol extract is adsorbed by a macroporous resin, eluted with 20%-30% ethanol to remove impurities, and then eluted with 75%-85% ethanol, and the elution flow rate is controlled at 3-5ml / min, the eluate was collected to obtain the refined solution of alcohol extraction.

[0090] The preparation method of the water extraction refined liquid is as follows: the water extract is concentrated under vacuum and reduced pressure to a relative density of 1.2-1.3, adding ethanol to make the ethanol con...

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Abstract

A preparation method of kidney tonifying and abdominal mass eliminating granule extract treating endometriosis is disclosed. The method includes 1) a step of raw material preparation, namely a step ofmixing danshen roots, sanqi and Sichuan lovage rhizome to form an alcohol extraction raw material, and mixing morinda roots, spica prunellae and twotoothed achyranthes roots to form a water extraction raw material; 2) a step of extract liquid preparation, namely a step of preparing an alcohol extract liquid from the alcohol extraction raw material through an alcohol extract liquid preparing process, and preparing a water extract liquid from the water extraction raw material through a water extract liquid preparing process; 3) a step of refined liquid preparation, namely a step of preparing the alcohol extract liquid into a refined alcohol extract liquid through a refined alcohol extract liquid preparing process, and preparing the water extract liquid into a refined water extract liquid through a refined water extract liquid preparing process; and 4) a step of extract preparation. The disclosed medicine is low in dosage, and has less ineffective components, thus reducing preparation ofextract, increasing the labor productivity, reducing dosage for patients in each time, maximally retaining the integrity and quantity of active ingredients, and simultaneously improving medicine bioavailability.

Description

technical field [0001] The invention relates to a method for preparing medicine, in particular to a method for preparing the extract of Yishen Xiaozheng Granules for treating endometriosis. Background technique [0002] Yishen Xiaozheng Granule is a compound preparation composed of Salvia Miltiorrhiza, Morinda officinalis, Sanqi, Prunella vulgaris, Chuanxiong and Achyranthes bidentata. Ectopic endometrial growth, improving dysmenorrhea, chronic pelvic pain, dyspareunia, abnormal menstruation and infertility caused by endometriosis. [0003] The traditional decoction preparation process is mostly obtained by decocting the original medicinal materials with water for many times, filtering, and merging the decoctions. These medicines have obtained certain therapeutic effects through clinical application, but there are also certain problems, such as poor taste of traditional Chinese medicines, poor stability, inconvenient carrying and storage for patients, and too many ineffecti...

Claims

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Application Information

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IPC IPC(8): A61K36/746A61P15/00
CPCA61K36/21A61K36/236A61K36/258A61K36/536A61K36/537A61K36/746A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61P15/00A61K2300/00
Inventor陈振振贡欣
OwnerCAPITAL UNIVERSITY OF MEDICAL SCIENCES