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Artificially weakened infectious bronchitis virus and application thereof

A chicken infectious and bronchitis technology, applied in the field of chicken infectious bronchitis live vaccine, can solve the problems of immune protection of non-popular virus strains, and achieve the effect of preventing chicken infectious bronchitis

Active Publication Date: 2013-06-12
ZHEJIANG YEBIO BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The purpose of the present invention is to solve the problem that current circulating vaccine strains cannot produce sufficient immune protection to circulating strains

Method used

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  • Artificially weakened infectious bronchitis virus and application thereof
  • Artificially weakened infectious bronchitis virus and application thereof
  • Artificially weakened infectious bronchitis virus and application thereof

Examples

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Embodiment Construction

[0013] The present invention is mainly implemented through the following technical solutions, and the following specific examples will be used to assist the description of the present invention. Those skilled in the art can better understand the present invention based on this, but the following examples are only used as technical demonstrations, and do not limit the present invention. Invention constitutes no limitation.

[0014] 1. The source and characteristics of bacteria and viruses

[0015] 1. Virus Isolation and Identification

[0016] In 2009, the applicant obtained a strain of chicken infectious bronchitis virus from a chicken farm in Zhejiang, which was identified as chicken infectious bronchitis virus 793 / B serotype through molecular biology tests, serological tests and other methods, and named it FNO-E strain.

[0017] 2. Passage weakening of chicken infectious bronchitis virus (FNO-E strain)

[0018] The virulence of the isolated chicken infectious bronchitis v...

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Abstract

The invention relates to an artificially weakened infectious bronchitis virus and application thereof. The artificially weakened infectious bronchitis virus uses the infectious bronchitis virus (IBV) which has good immunogenicity and is separated by an inventor to be passaged and attenuated, so as to obtain an attenuated strain FNO-E55 as a virus seed for production to prepare a safe and effective infectious bronchitis live vaccine. The strain used in the invention can effectively prevent occurrence of infectious bronchitis resulted from the infectious bronchitis virus (793 / B serotype) by aiming at a prevalence situation of the current domestic infectious bronchitis.

Description

technical field [0001] The invention relates to an artificially weakened chicken infectious bronchitis virus and a live chicken infectious bronchitis vaccine prepared from the virus, belonging to the veterinary biological product industry in the field of biotechnology. Background technique [0002] Infectious Bronchitis Virus (IBV) is a pathogen that causes acute and highly contagious respiratory diseases in chickens and belongs to the Coronaviridae family. At present, the virus is distributed globally, causing serious harm to the chicken industry in various countries and regions. The clinical features of the disease mainly include: coughing, sneezing, and tracheal rales; the kidneys are enlarged, pale, and urate deposits, with a typical appearance of "mottled kidney". Chickens of different ages, breeds and sexes are susceptible, and chicks often die due to respiratory tract or kidney infection; IBV has a wide range of tissue tropism and can replicate in many parts of respi...

Claims

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Application Information

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IPC IPC(8): C12N7/00A61K39/215A61P31/14C12R1/93
Inventor 嵇康张鹏超沈元曹玉飞林志晓
Owner ZHEJIANG YEBIO BIOTECH
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