Preparation method for 4-hydroxybenzyl cyanide

A technology of hydroxyphenylacetonitrile and p-hydroxybenzyl alcohol is applied in the fields of organic chemical synthesis and preparation of p-hydroxyphenylacetonitrile, and can solve the problem of low yield of p-hydroxyphenylacetonitrile finished products, low yield of p-hydroxyphenylacetonitrile, and easy occurrence of operation process. Danger and other problems, to achieve the effect of low cost, easy control and operation, and high yield of finished products

Active Publication Date: 2015-04-01
TIANJIN KERMEL CHEM REAGENT
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Problems solved by technology

[0002] p-Hydroxyphenylacetonitrile is mostly used as an intermediate in organic synthesis, and it is commonly used to synthesize aminoacidolol. The preparation of p-hydroxyphenylacetonitrile mostly uses an autoclave as a reaction vessel, and hydrogen is used as a reducing agent. The reaction process is difficult to control and the operation process is easy. Danger occurs, and the final yield of p-hydroxybenzonitrile is relatively low; the preparation of p-hydroxybenzonitrile is originally prepared by diazotization method, which has high cost and low yield of p-hydroxybenzonitrile finished product. The preparation method of hydroxyphenylacetonitrile all can not satisfy the demand for p-hydroxyphenylacetonitrile in the market now

Method used

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Embodiment Construction

[0021] The technical solutions of the present invention are described below to facilitate the understanding of those skilled in the art.

[0022] The preparation method of p-hydroxybenzonitrile, the preparation method of p-hydroxybenzonitrile comprises the following two steps:

[0023] (1) Preparation of p-hydroxybenzyl alcohol

[0024] ① Put p-hydroxybenzaldehyde as raw material into the reaction kettle, add methanol as solvent into the reaction kettle, then add an appropriate amount of water into the reaction kettle, and stir evenly;

[0025] ② Slowly add potassium borohydride to the reaction kettle in the above (1) step ①, monitor the temperature of the reaction kettle at 30-35°C, and react;

[0026] 3. Add acidic solution to the reaction kettle in the above (1) 2. step, and adjust the reaction kettle solution to neutrality;

[0027] ④ Centrifuge the reacted substance in the reaction kettle in the above (1) ③ step, remove the solution to obtain the crude product of p-hydr...

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Abstract

The invention belongs to the field of organic chemistry synthesis, and specifically relates to the field of preparation of 4-hydroxybenzyl cyanide. A preparation method for 4-hydroxybenzyl cyanide comprises preparation of benzylalcohol and preparation of 4-hydroxybenzyl cyanide by employing 4-hydroxybenzaldehyde as a raw material and potassium borohydride as a reducing agent. The preparation method for 4-hydroxybenzyl cyanide is performed at normal temperature and normal pressure; the operation process is fast, simple and easy to control; the reaction time in the preparation process is shorter; and the yield of the finished product of 4-hydroxybenzyl cyanide is 95% or more.

Description

technical field [0001] The invention belongs to the field of organic chemical synthesis, and more specifically relates to the field of preparation of p-hydroxyphenylacetonitrile. technical background [0002] p-Hydroxyphenylacetonitrile is mostly used as an intermediate in organic synthesis, and it is commonly used to synthesize aminoacidolol. The preparation of p-hydroxyphenylacetonitrile mostly uses an autoclave as a reaction vessel, and hydrogen is used as a reducing agent. The reaction process is difficult to control and the operation process is easy. Danger occurs, and the final yield of p-hydroxybenzonitrile is relatively low; the preparation of p-hydroxybenzonitrile is originally prepared by diazotization method, which has high cost and low yield of p-hydroxybenzonitrile finished product. The preparation method of hydroxyphenylacetonitrile all can not well satisfy the demand for p-hydroxyphenylacetonitrile in the market now. Contents of the invention [0003] The t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C255/36C07C253/16
Inventor 卢益民
Owner TIANJIN KERMEL CHEM REAGENT
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