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Oral care composition comprising a phenolic compound and antioxidant vitamins and vitamin derivatives

An anti-oxidant and oral care technology, which is applied in the direction of oral care, medical preparations containing active ingredients, cosmetic preparations, etc., can solve the problem that the anti-inflammatory properties of dentifrices have any effect, etc.

Inactive Publication Date: 2013-12-25
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No such antioxidants have been reported to have any effect on the anti-inflammatory properties of dentifrices containing phenolic compounds

Method used

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  • Oral care composition comprising a phenolic compound and antioxidant vitamins and vitamin derivatives
  • Oral care composition comprising a phenolic compound and antioxidant vitamins and vitamin derivatives
  • Oral care composition comprising a phenolic compound and antioxidant vitamins and vitamin derivatives

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] Toothpaste compositions having the ingredients shown in Table 1 were prepared. Comparative composition 1Z is conventionally prepared containing silica abrasive, PVME / MA (GANTREZ ) Glycerin / sorbitol based toothpaste with anti-tartar agent, sodium fluoride and other conventional ingredients. Triclosan was present in an amount of 0.3%. Composition 1A of the present invention was essentially the same except that vitamin E acetate and DL-panthenol as indicated in Table 1 were added in the final mixing step.

[0096] Table 1: Toothpaste composition (percentage by weight)

[0097]

[0098] 1 Toothpaste base includes the following ingredients: silica powder, glycerin, sorbitol, water, GANTREZ Sodium Lauryl Sulfate, Sodium Hydroxide, Titanium Dioxide, Fragrance, Sodium CMC, t-Carrageenan, Sodium Fluoride, Sodium Saccharin

Embodiment 2

[0100] Toothpaste compositions having the ingredients shown in Table 2 were prepared. Comparative composition 2Z is ​​conventionally prepared containing silica abrasive, PVME / MA (GANTREZ ) sorbitol-based toothpaste with anti-tartar agent, sodium fluoride and other conventional ingredients. Triclosan was present in an amount of 0.3%. Composition 2A of the present invention was essentially the same except that vitamin E acetate and DL-panthenol as indicated in Table 2 were added in the final mixing step.

[0101] Table 2: Toothpaste composition (percentage by weight)

[0102]

[0103] 2 Toothpaste base includes the following ingredients: sorbitol, water, silica powder, GANTREZ Sodium Lauryl Sulfate, Sodium Hydroxide, Titanium Dioxide, Fragrance, t-Carrageenan, Glycerin, Sodium Fluoride, Sodium Saccharin

Embodiment 3

[0105] Toothpaste compositions having the ingredients shown in Table 3 were prepared. Comparative composition 3Z is conventionally prepared containing silica abrasive, PVME / MA (GANTREZ ) Glycerin / sorbitol based toothpaste with anti-tartar agent, sodium fluoride and other conventional ingredients. Triclosan was present in an amount of 0.3%. Compositions 3A-3F of the present invention were essentially the same except that the vitamins as indicated in Table 3 were added in the final mixing step.

[0106] Table 3: Toothpaste composition (weight percent)

[0107]

[0108] 3 Toothpaste base includes the following ingredients: water, silica powder, sorbitol, glycerin, GANTREZ Sodium Lauryl Sulfate, Sodium Hydroxide, Sodium CMC, Propylene Glycol, Titanium Dioxide, Sodium Saccharin, Sodium Fluoride

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PUM

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Abstract

An oral care composition comprises an antibacterial phenolic compound and a vitamin or vitamin derivative component comprising one to a plurality of antioxidant vitamin or vitamin derivatives. In one embodiment the vitamin or vitamin derivative component comprises vitamin E and vitamin E acetate and optionally one or more additional vitamin or vitamin derivatives. In another embodiment the vitamin or vitamin derivative component comprises an antioxidant vitamin or vitamin derivative and a source of vitamin B5. A method of oral care comprises applying a composition as described above to an oral surface of a subject.

Description

[0001] This application is a divisional application of an invention patent application with an application date of November 10, 2005, an application number of 200580047685.4, and an invention title of "Oral Care Composition Containing Phenolic Compounds, Antioxidant Vitamins and Vitamin Derivatives". [0002] Cross References to Related Applications [0003] This application claims the benefit of previously filed US Provisional Patent Application Serial No. 60 / 632,480, filed December 2, 2004, the contents of which are incorporated herein by reference. Background of the invention [0004] Many phenolic compounds have antibacterial and anti-inflammatory properties and are known to be useful as antibacterial and / or anti-inflammatory agents in oral care compositions such as mouthwashes and dentifrices. Examples of such phenolic compounds include carvacrol, thoxyphenol, 4-hexylresorcinol (4-hexyl-1,3-dihydroxybenzene), bromochlorophenol (2,2'-methylene bis(4-chloro-6-bromophenol))...

Claims

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Application Information

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IPC IPC(8): A61K8/67A61K8/33A61Q11/00
CPCA61K8/347A61K8/498A61K8/676A61K8/678A61K31/085A61K31/353A61K31/355A61K31/375A61K31/555A61Q11/00
Inventor D.S.谢尔K.帕纳利根L.弗鲁吉H.M.特里维迪徐韬
Owner COLGATE PALMOLIVE CO
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