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Composition containing r-aminobutyric acid, taurine and antiepileptic drugs

A technology of aminobutyric acid and taurine, which is applied in the direction of drug combination, active ingredients of anhydride/acid/halide, medical preparations containing active ingredients, etc., can solve the problems of complicated and incomplete elucidation of epilepsy pathogenesis

Inactive Publication Date: 2014-01-15
HUNAN UNIV OF TECH
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AI Technical Summary

Problems solved by technology

[0002] The pathogenesis of epilepsy is very complex and has not yet been fully elucidated

Method used

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Experimental program
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example

[0027] Table I

[0028] Component Weight Embodiment one Embodiment two Topiramate 500g 250g starch 50g 50g 10% starch slurry 24g 24g dry starch 23g 23g Magnesium stearate 3g (about 0.5%) 3g (about 0.5%) Made into 1000 tablets (each tablet contains 0.5g of topiramate) Made into 1000 tablets (each tablet contains 0.25g of topiramate)

[0029] Pass topiramate through 80-mesh sieve, mix with starch, add starch slurry to make soft material, granulate with 14-mesh sieve, dry at 70-80°C, granulate with 12-mesh sieve, add dry starch and magnesium stearate Mix well and press into tablets to obtain (the formula ratio is shown in Table 1).

[0030]

[0031] Table II

[0032] Component Weight Embodiment three Embodiment Four r-aminobutyric acid 300g 6000g taurine 300g 6000g starch 266g 266g 16% starch slurry 85g 85g Talc powder (5%) 25g ...

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Abstract

The invention relates to a composition containing r-aminobutyric acid, taurine and antiepileptic drugs selected from gabapentin, oxcarbazepine, valproic acid, topiramate, phenytoin and the like, and relates to purposes thereof in the aspects of preventing, delaying or treating the epileptic seizure, in particular resisting epilepsia, scavenging free radicals and restraining lipid peroxidation in the epileptic seizure.

Description

technical field [0001] The present invention relates to a combination comprising r-aminobutyric acid and taurine and anti-epileptic drugs selected from gabapentin, oxcarbazepine, valproic acid, topiramate and phenytoin, and its role in preventing, delaying or treating epileptic seizures, especially It is used for antiepileptic and inhibiting lipid peroxidation in epileptic seizures. Background technique [0002] The pathogenesis of epilepsy is very complex and has not yet been fully elucidated. In the 1980s, beginners proposed three major pathogenic factors of epilepsy: 1) genetic predisposition; 2) epileptic pathological changes in the brain; 3) precipitating factors, such as biochemical (excitatory, inhibitory amino acids) or immunological aspects changes etc. The treatment of epilepsy is mainly to control epileptic seizures through drugs. The antiepileptic activity of drugs is achieved by acting on one or more targets in brain tissue, including ion channels, neurotransm...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/197A61P25/08A61P25/22A61P25/24A61P25/06A61P25/04A61P25/18A61K31/185A61K31/195A61K31/55A61K31/19A61K31/7048A61K31/4166
Inventor 邓燕何农跃肖细梅张立明刘可可傅欣
Owner HUNAN UNIV OF TECH
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