Preparation method of Qingmei cold tablet and application of Qingmei cold tablet in drugs for inhibiting stomach cancer cell MFC from cell proliferation

A Qingmei Ganmao tablet and extraction technology are applied in the directions of drug combinations, medical preparations containing active ingredients, antipyretics, etc., which can solve the problems of large dosage, rough process, and many impurities for patients, and reduce the dosage and dosage of medicines. No bitter taste, small dosage effect

Inactive Publication Date: 2014-05-07
SHANDONG TUMOR HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Qingmei Ganmao Granules. However, the method of extracting volatile oil and decocting in water is rough and backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take. , seriously affecting the clinical application of this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 200g of Artemisia annua, 267g of five-finger tangerine, 134g of Elsholtzia, 200g of dog's liver, 134g of licorice, 134g of Centella asiatica, and 267g of ganmei, add Artemisia annua and Elsholtzia to CO 2 In the supercritical extractor, ethanol is used as the entrainer, the entrainer accounts for 5% of the total extraction solvent, the extraction pressure is 25MPa, the temperature is 40°C, and CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 200min, and the supercritical extract is obtained for use; take the rest of the traditional Chinese medicine, crush it, add 5L of 50% ethanol, and put it into a microwave extraction device for microwave extraction. The extraction power is 700W, and the extraction is performed twice. For 8 minutes each time, combine the extracts, concentrate, add to the Dl01 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume of the eluate, recover the ethanol under reduced pressure, conce...

Embodiment 2

[0034] Take 200g of Artemisia annua, 267g of five-finger tangerine, 134g of Elsholtzia, 200g of dog's liver, 134g of licorice, 134g of Centella asiatica, and 267g of ganmei, add Artemisia annua and Elsholtzia to CO 2 In the supercritical extractor, ethanol is used as the entrainer, the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 30 MPa, the temperature is 50 ℃, and CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; take the remaining traditional Chinese medicine, crush it, add 5L of 50% ethanol, and put it into a microwave extraction device for microwave extraction, extraction power 600W, extraction 2 times, For 5 minutes each time, combine the extracts, concentrate, add to the Dl01 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume of the eluate, recover the ethanol under reduced pressure, concentrate and d...

Embodiment 3

[0037] Take 200g of Artemisia annua, 267g of five-finger tangerine, 134g of Elsholtzia, 200g of dog's liver, 134g of licorice, 134g of Centella asiatica, and 267g of ganmei, add Artemisia annua and Elsholtzia to CO 2 In the supercritical extractor, ethanol is used as the entrainer. The entrainer accounts for 6% of the total extraction solvent. The extraction pressure is 15MPa, the temperature is 30°C, and CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 220min, and the supercritical extract is obtained for use; take the remaining Chinese medicine, crush it, add 5L of 50% ethanol, and put it into a microwave extraction device for microwave extraction, extraction power 800W, extraction 2 times, For 10 minutes each time, combine the extracts, concentrate, add to the Dl01 macroporous adsorption resin column, eluted with 50% ethanol, collect 5 times the column volume of the eluate, recover the ethanol under reduced pressure, concentrate and dry to obtain the microwave...

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PUM

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly provides a preparation method and application of a Qingmei cold tablet. The preparation method comprises the following steps: by using 200g of southernwood, 267g of finger citron, 134g of elsholtzia, 200g of dicliptera, 134g of licorice, 134g of cat's-foot and 267g of holly root as active pharmaceutical ingredients, carrying out supercritical extraction and microwave extraction so that the glycyrrhizic acid content is greatly enhanced. The invention also provides application of the Qingmei cold tablet in preparing drugs for inhibiting mouse stomach cancer cell MFC from cell proliferation.

Description

[0001] Application in reproductive medicine Technical field [0002] The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a preparation method of a green plum cold tablet and its application in a medicine for inhibiting the proliferation of mouse gastric cancer cells MFC cells. Background technique [0003] The standard number of Qingmei Ganmao Granules is WS-11318 (ZD-1318)-2002, which is recorded in the Internal Medicine Spleen and Stomach Division of the National Standards of Chinese Patent Medicine. It is made from 200g of Artemisia annua, 267g of five-finger tangerine, 134g of Elsholtzia, 200g of dog's liver, 134g of licorice, 134g of Centella asiatica, and 267g of ganmei. It has cooling and antipyretic effects. Used for Fengreganmao, headache, cough, nasal congestion. [0004] In the prior art, there has not been a report on the use of supercritical and microwave technology in the extraction and preparation of Qingmei Ganma...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K9/20A61P35/00A61P11/00A61P31/12A61P29/00A61P11/14A61P11/02
Inventor 孙波
Owner SHANDONG TUMOR HOSPITAL
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