Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

N- substituted benzenepropanamide and benzenepropenamide for use in prevention or treatment of affective disorders

A kind of emotional disorder, -OR6 technology, applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, organic active ingredients, etc.

Inactive Publication Date: 2014-05-28
NOVAREMED LTD
View PDF3 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since most antidepressants (such as SSRIs and tricyclic agents) exhibit some sedative effects at high doses, it was inferred that the analgesic activity elicited by the compounds of this application is not dependent on central nervous system actions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • N- substituted benzenepropanamide and benzenepropenamide for use in prevention or treatment of affective disorders
  • N- substituted benzenepropanamide and benzenepropenamide for use in prevention or treatment of affective disorders
  • N- substituted benzenepropanamide and benzenepropenamide for use in prevention or treatment of affective disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0168] The open field test: exploratory motor activity.

[0169] This method is one of the most popular methods for evaluating animal behavior. It tests both motor parameters and anxiety (Prut et al.). Individual mice were placed on a new 50x50 cm Plexiglas platform, the floor of which was divided into 3 numerical areas; peripheral area 1 , middle area 2 and most central area 3 . Animal behavior in the open field was videotaped for 20 min and animal behavior was subsequently digitally analyzed using Noldus software. Assays included general motility: moving distance, speed and strong mobility, and anxiety parameters including frequency of visits to the central area, time spent in the inner area and number of feeding events in the central area. The more the animal stayed and moved in the center, the less anxious it was.

[0170]

[0171] This method was used to evaluate the anxiolytic effect of the compounds of the invention as follows.

[0172] Forty 9-week-old naive m...

Embodiment 2

[0183] forced swim test

[0184] This is one of the most widely used preclinical tools for screening antidepressant activity in acute experiments and was first described by Porsolt et al. (1977). This experiment is based on the observation that rats or mice exhibit immobility when placed in an inescapable cylinder of water. This behavior is considered behavioral desperation, the exact opposite of a positive way of coping with stressful conditions. Antidepressants will reduce immobility and increase aggressive behavior in rodents to escape desperate conditions. This was evidenced by: increases in swimming time, distance traveled, speed and attempts to climb walls (strong mobility). FST is considered a good screening tool and has good reliability and predictive validity.

[0185] The experiment was performed in male mice (Balbic Harlan IL) after 4 days of drug administration (90 minutes after the last drug administration). A glass cylinder (18cm diameter and 20cm depth) wa...

Embodiment 3

[0190] elevated plus maze

[0191] This model exploits rodents' natural fear of avoiding open and elevated places. The apparatus consists of a plus maze with two closed and two opposing open arms, elevated above a base plate. Naive animals spend only about 30% of the test time in the open arm, yet treatment with BDZ significantly increases exploration of the open arm (Pellow et al.). This is one of the most widely used models for studying anxiety-like behavior. The maze consisted of two opposing open arms (40x10 cm) and two opposing closed arms (40x10 cm with 40 cm walls) on a platform 50 cm above the floor. Mazes are based on aversion to open areas, so in mice displaying anxiety, restricting movement into the closed arms is expected.

[0192] Groups of mice were treated as in Example 2 and the elevated plus maze test was performed on day 8. This experiment is another experiment used to evaluate the anxiolytic effect of the drug of the present invention.

[0193] Mice wer...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Compounds for use in the treatment or prophylaxis of an affective disorder are provided. Compound is represented by formula I in which the dotted line represents a single or a double bond; and R5 and R5' are independently -H, -OH or -OR6, where R6 is a linear or branched C1-C4 alkyl; X is -CH2O-; Z is -CH2OmicronEta2O-,-CH(CH3)CH2O- or -CH2CH(CH3)O-; m is 1; and n is an integer of 1-5; or a pharmaceutically acceptable salt, prodrug, metabolite, or hydrate thereof.

Description

technical field [0001] The present invention relates to the treatment or prevention of affective disorders such as anxiety and depression and provides methods of treating or preventing affective disorders and the use of certain compounds in the manufacture of medicaments for the treatment or prevention of affective disorders in humans and non-human animals. Background technique [0002] Affective disorders are multifaceted (including biological, behavioral, social, and psychological factors) psychiatric disorders. Affective disorders are characterized by mood changes as the primary clinical manifestation. Such disorders include depression, anxiety, bipolar disorder, postpartum depression, dysthymia, seasonal affective disorder, dissociative affective disorder, panic disorder, eating disorder, obsessive-compulsive disorder, and post-traumatic stress disorder. When mood disturbances (depression, anxiety, elation, and excitement) are severe, patients may additionally experienc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/165A61P25/22A61P25/24
CPCA61K31/165A61K47/10C07C233/22A61K47/60C07C235/34A61P25/00A61P25/22A61P25/24
Inventor E·卡普兰I·吉拉德
Owner NOVAREMED LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com