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A kind of pharmaceutical composition containing luteolin and its application

A technology of luteolin and composition, which is applied in the field of medicine to achieve the effects of reducing production and packaging costs, reducing dosage, and increasing treatment compliance

Inactive Publication Date: 2015-11-18
郝敬卫
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no report about the combined application of olmesartan medoxomil and luteolin in the prior art, especially no antihypertensive report after the combined application of the two

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Study on the curative effect of combined use of olmesartan medoxomil and luteolin on hypertensive rats

[0021] A total of 40 8-week-old spontaneous hereditary hypertensive rats (SHR) were purchased from Shanghai Slack Experimental Animal Co., Ltd. According to body weight, they were randomly divided into model control group, luteolin group, olmesartan group and combination drug group, totally 4 groups, 10 rats in each group. Luteolin and olmesartan medoxomil were formulated with an appropriate amount of purified water to prepare a medicinal solution, and the rats in each group were intragastrically administered for 10 weeks, and the doses were as follows:

[0022] Model control group: the same volume of purified water;

[0023] Luteolin group: 10mg / (kg?d) luteolin;

[0024] Olmesartan group: 1mg / (kg?d) olmesartan medoxomil;

[0025] Combined medication group: 10mg / (kg?d) luteolin + 1mg / (kg?d) olmesartan medoxomil.

[0026] Tail artery systolic blood pres...

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PUM

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Abstract

The invention discloses a pharmaceutical composition containing cyanidenon and use thereof. The active component of the pharmaceutical composition is prepared from olmesartan medoxomil and cyanidenon, and the weight ratio of the olmesartan medoxomil to the cyanidenon is preferably 1:(2-20). The blood pressure can be slowly and stably reduced by adopting low-dosage cyanidenon combined with olmesartan medoxomil, so that protection of structure and function of the hypertensive target organ is facilitated, and the occurrence rate of a cardiovascular event is further reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a pharmaceutical composition, in particular to a pharmaceutical composition containing a small dose of luteolin and its application. Background technique [0002] Hypertension is the most common cardiovascular disease and has become a major public health problem worldwide. According to statistics from the national health department, by the end of 2006, the number of hypertensive patients in my country had reached 160 million, and more than 3 million new patients were added every year. [0003] Hypertension is a syndrome with very complicated etiology and pathogenesis. Once diagnosed, it requires life-long medication. At present, domestic and foreign medical circles generally tend to use two antihypertensive drugs with different mechanisms of action in combination. According to the sixth report of the National Committee on the Prevention, Detection, Evaluation, and Treatment of Hy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4178A61P9/12A61K31/352
Inventor 陈金杰
Owner 郝敬卫
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