A kind of pharmaceutical composition containing luteolin and its application
A technology of luteolin and composition, which is applied in the field of medicine to achieve the effects of reducing production and packaging costs, reducing dosage, and increasing treatment compliance
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[0020] Example 1 Study on the curative effect of combined use of olmesartan medoxomil and luteolin on hypertensive rats
[0021] A total of 40 8-week-old spontaneous hereditary hypertensive rats (SHR) were purchased from Shanghai Slack Experimental Animal Co., Ltd. According to body weight, they were randomly divided into model control group, luteolin group, olmesartan group and combination drug group, totally 4 groups, 10 rats in each group. Luteolin and olmesartan medoxomil were formulated with an appropriate amount of purified water to prepare a medicinal solution, and the rats in each group were intragastrically administered for 10 weeks, and the doses were as follows:
[0022] Model control group: the same volume of purified water;
[0023] Luteolin group: 10mg / (kg?d) luteolin;
[0024] Olmesartan group: 1mg / (kg?d) olmesartan medoxomil;
[0025] Combined medication group: 10mg / (kg?d) luteolin + 1mg / (kg?d) olmesartan medoxomil.
[0026] Tail artery systolic blood pres...
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