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Method for detection of methamphetamine in blood

A detection method, a methamphetamine technology, applied in Raman scattering, material excitation analysis, etc., can solve the problems of low sensitivity, slow analysis speed, complicated operation, etc., and achieve the effect of improving sensitivity, reducing detection limit, and enhancing Raman scattering

Active Publication Date: 2017-08-22
NANKAI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The purpose of the present invention is to propose a method for detecting methamphetamine in blood in order to solve the problems of complex operation, slow analysis speed and low sensitivity in the prior art

Method used

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  • Method for detection of methamphetamine in blood
  • Method for detection of methamphetamine in blood
  • Method for detection of methamphetamine in blood

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Embodiment 1 - field enhancement effect of optical functional element

[0069] Please refer to Fig. 4 (a), which is the Raman scattering of the methamphetamine aqueous solution measured on the glass slide; Fig. 4 (b) is the Raman scattering of the methamphetamine aqueous solution of the same concentration measured on the optical functional element under the same experimental conditions Raman scattering.

[0070] Figure 4(a) and Figure 4(b) show that the Raman scattering of methamphetamine can hardly be measured on the glass slide, but on the optical functional element, very clear Raman scattering can be measured, which shows that due to the optical functional element The effect of submicron silver particles on the Raman scattering signal of the methamphetamine aqueous solution produced a significant enhancement effect.

[0071] Please refer to Fig. 5(a) for Raman scattering of blood measured on a quartz glass slide; Fig. 5(b) for Raman scattering of blood measured on a...

Embodiment 2

[0074] Example 2 - Detecting whether the blood sample to be tested contains methamphetamine

[0075] The blood samples of persons suspected of using methamphetamine contain two substances, methamphetamine and blood, and it has been reported in the literature that both methamphetamine and blood have Raman scattering. Raman scattering of an aqueous sample.

[0076] Table 1.1 Raman peaks of three samples

[0077] methamphetamine, cm -1

[0078] According to the information in Table 1.1, it is found that there are many identical or similar Raman peaks among the methamphetamine samples, blood samples of healthy people and blood samples of suspected drug addicts, including 853cm -1 、1002cm -1 、1028cm -1 、1159cm -1 、1392cm -1 、1454cm -1 and 1560cm -1 (See the data with * in the first column of the above table), it is impossible to judge whether these Raman peaks belong to the blood or methamphetamine in the blood samples of the suspected drug users. This embodiment...

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Abstract

The invention provides a method for detecting methamphetamine in blood. By placing the blood sample to be detected, the blood sample of a healthy person and the methamphetamine sample on an optical functional element, the blood sample to be detected, the blood sample of a healthy person and the methamphetamine sample are respectively measured. According to the Raman spectrum of the blood sample to be tested, the blood sample of healthy people and the Raman spectrum of the methamphetamine sample, it is judged whether the blood sample to be tested contains methamphetamine, because the optical functional element can produce a better field enhancement effect Therefore, clear Raman scattering can be measured. When the methamphetamine aqueous solution is on the optical functional element, the Raman scattering signal can produce a significant enhancement effect. Even if the blood contains a small amount of methamphetamine, a clearer Raman can still be measured. Scattering, so as to effectively improve the Raman detection sensitivity, reduce the detection limit, and enhance the Raman scattering of the sample.

Description

[0001] 【Technical field】 [0002] The invention relates to the technical field of drug detection, in particular to a method for detecting methamphetamine in blood. [0003] 【Background technique】 [0004] Methamphetamine, also known as methamphetamine, methamphetamine, is a pure white crystal, crystal clear, and looks like ice, commonly known as "ice". It is the main component of "ecstasy", has a strong central nervous system excitatory effect, has a strong mental dependence, and has serious harm to the human body. The abuse of methamphetamine drugs has brought great harm to people's lives and property. Therefore, in the work of forensic science, it is of great significance to realize the trace, sensitive, accurate, rapid and automatic detection of methamphetamine. [0005] At present, there are many detection methods at home and abroad. Chromatography has the advantages of high separation efficiency, fast analysis speed, good selectivity, and simultaneous analysis of multipl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65
Inventor 陈平王岩张凯林列李星张丰
Owner NANKAI UNIV
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