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Method for detecting methylamphetamine in blood

A detection method, a methamphetamine technology, applied in Raman scattering, material excitation analysis, etc., can solve the problems of complex operation, slow analysis speed, and low sensitivity, and achieve the effect of improving sensitivity, reducing detection limit, and enhancing Raman scattering

Active Publication Date: 2014-10-29
NANKAI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to propose a method for detecting methamphetamine in blood in order to solve the problems of complex operation, slow analysis speed and low sensitivity in the prior art

Method used

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  • Method for detecting methylamphetamine in blood
  • Method for detecting methylamphetamine in blood
  • Method for detecting methylamphetamine in blood

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1 - field enhancement effect of optical functional element

[0064] Please refer to Fig. 4 (a), which is the Raman scattering of the methamphetamine aqueous solution measured on the glass slide; Fig. 4 (b) is the Raman scattering of the methamphetamine aqueous solution of the same concentration measured on the optical functional element under the same experimental conditions Raman scattering.

[0065] Figure 4(a) and Figure 4(b) show that the Raman scattering of methamphetamine can hardly be measured on the glass slide, but on the optical functional element, very clear Raman scattering can be measured, which shows that due to the optical functional element The effect of submicron silver particles on the Raman scattering signal of the methamphetamine aqueous solution produced a significant enhancement effect.

[0066] Please refer to Fig. 5(a) for Raman scattering of blood measured on a quartz glass slide; Fig. 5(b) for Raman scattering of blood measured on a...

Embodiment 2

[0069] Example 2 - Detecting whether the blood sample to be tested contains methamphetamine

[0070] The blood samples of persons suspected of using methamphetamine contain two substances, methamphetamine and blood, and it has been reported in the literature that both methamphetamine and blood have Raman scattering. Raman scattering of an aqueous sample.

[0071] Table 1.1 Raman peaks of three samples

[0072] methamphetamine, cm -1

[0073] According to the information in Table 1.1, it is found that there are many identical or similar Raman peaks among the methamphetamine samples, blood samples of healthy people and blood samples of suspected drug addicts, including 853cm -1 、1002cm -1 、1028cm -1 、1159cm -1 、1392cm -1 、1454cm -1 and 1560cm -1 (See the data with * in the first column of the above table), it is impossible to judge whether these Raman peaks belong to the blood or methamphetamine in the blood samples of the suspected drug users. This embodiment...

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Abstract

The invention provides a method for detecting methylamphetamine in blood. The method comprises the steps of putting a to-be-detected blood sample, a blood sample of healthy people and a methylamphetamine sample on an optical functional element, respectively measuring Raman spectra of the to-be-detected blood sample, Raman spectra of the blood sample of the healthy people and Raman spectra of the methylamphetamine sample, and judging whether the to-be-detected blood sample contains methylamphetamine or not according to the Raman spectra of the to-be-detected blood sample, the Raman spectra of the blood sample of the healthy people and the Raman spectra of the methylamphetamine sample. The method has the beneficial effects that as the optical functional element can generate a preferable field enhancement effect, clear Raman scattering can be measured; when an aqueous solution of methylamphetamine is located on the optical functional element, the obvious enhancement effect can be generated to a Raman scattering signal, and the relatively clear Raman scattering can still be measured even the blood contains trace amount of methylamphetamine, so that the detection sensitivity of the Raman scattering is effectively improved, the detection limit is reduced, and the Raman scattering of the sample is enhanced.

Description

【Technical field】 [0001] The invention relates to the technical field of drug detection, in particular to a method for detecting methamphetamine in blood. 【Background technique】 [0002] Methamphetamine, also known as methamphetamine, methamphetamine, is a pure white crystal, crystal clear, and looks like ice, commonly known as "ice". It is the main component of "ecstasy", has a strong central nervous system excitatory effect, has a strong mental dependence, and has serious harm to the human body. The abuse of methamphetamine drugs has brought great harm to people's lives and property. Therefore, in the work of forensic science, it is of great significance to realize the trace, sensitive, accurate, rapid and automatic detection of methamphetamine. [0003] At present, there are many detection methods at home and abroad. Chromatography has the advantages of high separation efficiency, fast analysis speed, good selectivity, and simultaneous analysis of multiple components, e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
Inventor 陈平王岩张凯林列李星张丰
Owner NANKAI UNIV
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