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A pharmaceutical composition for preventing postoperative intestinal adhesion and its application

A technology for intestinal adhesion and prevention, applied in the field of medicine, can solve the problem of no euphorbia dienol intestinal adhesion in literature reports and the like, and achieve the effect of preventing intestinal adhesion, being easy to accept, and having less toxic and side effects

Inactive Publication Date: 2017-01-11
THE THIRD PEOPLES HOSPITAL OF QINGDAO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Through searching the domestic and foreign literature, there is no literature report on the prevention of postoperative intestinal adhesion by euspienol

Method used

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  • A pharmaceutical composition for preventing postoperative intestinal adhesion and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment one: the preparation of eugenol

[0014] Gansui medicinal material 5.0kg, washed, dried, crushed through 80-mesh sieve for later use; the medicinal material powder was soaked in 95% ethanol, 25L each time, warmed at 50°C, filtered, repeatedly extracted until colorless, combined filtrate, and reduced pressure Recover dry extract 1.0kg. Mix the dry extract with double the amount of diatomaceous earth, and use ethyl acetate, 2.5L each time, to repeatedly extract until colorless, combine the ethyl acetate liquid, and dry under reduced pressure to obtain crude euphordienol. thing.

[0015] Put the crude euphorpadienol extract on a silica gel chromatography column, elute with petroleum ether-ethyl acetate (100:2) mixed solution, collect the eluate in 150 L of elution, detect with TLC, and concentrate to dryness under reduced pressure to obtain Euphorbiadienol crude product.

[0016] Dissolve 90% acetonitrile of the crude euphorpadienol to obtain its saturated so...

Embodiment 2

[0017] Embodiment two: the preparation of eugenol

[0018] Gansui medicinal material 5.0kg, washed, dried, crushed through a 120-mesh sieve for later use; the medicinal material powder was soaked in 90% ethanol, 50L each time, warmed at 40°C, filtered, repeatedly extracted until colorless, combined filtrate, and reduced pressure Recover dry extract 1.1kg. Mix the dry extract with double the amount of diatomaceous earth, and use ethyl acetate, 2.5L each time, to repeatedly extract until colorless, combine the ethyl acetate liquid, and dry under reduced pressure to obtain crude euphordienol. thing.

[0019] Put the crude euphorpadienol extract on a silica gel chromatography column, elute with petroleum ether-ethyl acetate (100:2) mixed solution, collect the eluate in 180 L, detect by TLC, and concentrate to dryness under reduced pressure to obtain Euphorbiadienol crude product.

[0020] Dissolve 90% acetonitrile of the crude euphorpadienol to obtain its saturated solution, ce...

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Abstract

The invention discloses a medicine composition for preventing the postoperative intestinal adhesion and the application thereof. The medicine composition is prepared from an active ingredient and an additive; the active ingredient is euphadienol. Through the adoption of the medicine composition, the intestinal function of a patient can be recovered quickly, the patient can take food ahead of schedule, and the medicine composition has no adverse effects.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for preventing postoperative intestinal adhesion and its application. Background technique [0002] Postoperative adhesions are the adhesions between the abdominal and pelvic parietal peritoneum and the visceral peritoneum, and between the visceral peritoneum and the visceral peritoneum after surgery. Studies have found that the incidence of adhesions after surgery is as high as 90%, and can lead to serious complications, including intestinal obstruction, abdominal pain, and female infertility. Symptoms in patients with postoperative intestinal adhesions may vary depending on the degree and location of the adhesions. Mild cases may have no symptoms, or occasionally mild abdominal pain and bloating after eating; severe cases may often be accompanied by abdominal pain and bloating, poor exhaust, belching, hiccups, and dry stools. Normal i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/575A61P41/00
CPCA61K31/575
Inventor 殷德昌付青
Owner THE THIRD PEOPLES HOSPITAL OF QINGDAO
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