Unsaturated ester and preparation method thereof

A technology of unsaturated and threonine, which is applied in the field of unsaturated esters with sulfonic acid groups, carboxyl groups and amino groups, can solve the problems of interfering with HIV surface proteins and not functioning, so as to enhance adsorption and improve dispersibility , improve the effect of retarding

Active Publication Date: 2015-02-11
JIANGSU UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, German scientists have discovered a kind of threonine in human blood. Experiments have found that it can prevent HIV from attaching and invading body cells. By interfering with the surface protein of HIV, it cannot function

Method used

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  • Unsaturated ester and preparation method thereof
  • Unsaturated ester and preparation method thereof
  • Unsaturated ester and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Table 1

[0038]

[0039] 1) Weigh Thr 1.74g (0.01mol), p-TSA 2.375g (0.0125mol), and HQ 0.01g, add

[0040] Into the reactor, stir and heat until the mixture is transparent;

[0041] 2) After adding cyclohexane, a water-carrying agent accounting for 20% of the total volume of the reactants, the temperature was raised to 110° C., and 1.29 grams (0.015 mol) of MAA was started to be added dropwise;

[0042] 3) After the dropwise addition is completed, the product is obtained after the insulation reaction for 15 hours.

Embodiment 2

[0044] Table 2

[0045]

[0046] 1) Weigh 1.74 grams (0.01mol) of Thr, 1.995 grams (0.0105mol) of p-TSA, and 0.031 grams of HQ, add them into the reactor, stir and heat until the mixture becomes transparent;

[0047]2) After adding cyclohexane, a water-carrying agent accounting for 40% of the total volume of the reactants, the temperature was raised to 110° C., and 1.722 grams (0.02 mol) of MAA was started to be added dropwise;

[0048] 3) After the dropwise addition is completed, the product is obtained after the insulation reaction for 14 hours.

Embodiment 3

[0050] table 3

[0051] material

Thr

MAA

p–TSA

Esterification rate

Molar weight (mol)

0.01

0.02

0.0125

30％

[0052] mass (g)

1.74

1.722

2.375

[0053] 1) Weigh 1.74 grams (0.01mol) of Thr, 2.375 grams (0.0125mol) of p-TSA, and 0.021 grams of HQ, add them into the reactor, stir and heat until the mixture becomes transparent;

[0054] 2) After adding cyclohexane, a water-carrying agent accounting for 30% of the total volume of the reactants, the temperature was raised to 105° C., and 1.722 g (0.02 mol) of MAA was started to be added dropwise;

[0055] 3) After the dropwise addition is completed, the product is obtained after the insulation reaction for 13 hours.

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PUM

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Abstract

The invention discloses an unsaturated ester prepared from an amino acid which takes threonine as a representative and contains hydroxyl groups. The invention further discloses a preparation method of the unsaturated ester shown in the specification. The preparation method comprises the following steps: modifying an unsaturated carboxylic acid with the amino acid, carrying out an esterification reaction so as to esterify the threonine containing hydroxyl groups by virtue of the unsaturated carboxylic acid, and feeding carboxyl groups, amino groups and sulfonic groups into the hydroxyl groups of the amino acid so as to synthesize an unsaturated amino acid ester.

Description

technical field [0001] The invention belongs to amino acid ester compounds, and specifically relates to a method for synthesizing an unsaturated ester with carboxyl, amino and sulfonic acid groups with threonine. Background technique [0002] Amino acid is the basic unit of protein and the basic substance of protein required for animal nutrition. There are only 22 kinds of amino acids that can be digested, absorbed and utilized by the human body, which are mainly used in medicine, food and feed industries. [0003] According to reports, in 2013, the scale of the global feed amino acid industry reached 3.84 million tons, while China's feed amino acid production accounted for 39.62% of the global total. Due to the greatly increased demand in the European and American markets, the demand for amino acid exports has been stimulated, and the current price of threonine is basically at the bottom. [0004] Threonine is mainly used in medicine, chemical reagents, food fortifiers, f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C309/30C07C229/22C07C303/32C07C227/16C08F220/38C04B24/04
Inventor 彭银仙徐庆涛崔崇
Owner JIANGSU UNIV OF SCI & TECH
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