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Qualitative and quantitative detection method of compound Japanese Ardisia Herb tablets

A quantitative detection method and technology of low ground tea, applied in the direction of measuring devices, instruments, scientific instruments, etc.

Inactive Publication Date: 2015-02-11
JIUZHITANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned methods all only establish the method for determining the content of petogenin, and cannot comprehensively and reliably control the quality of the preparation.
[0003] Generally speaking, the existing qualitative and quantitative detection methods cannot effectively control the quality of compound Aodi tea tablets, which will affect the production and quality assurance of the product and its Clinical efficacy

Method used

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  • Qualitative and quantitative detection method of compound Japanese Ardisia Herb tablets
  • Qualitative and quantitative detection method of compound Japanese Ardisia Herb tablets
  • Qualitative and quantitative detection method of compound Japanese Ardisia Herb tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] Compound Aodi Tea Tablets (Film-Coated Tablets) Batch Number: 20111204

[0089] (1) Identification:

[0090] The microscopic identification of Aodi tea includes the following steps: Take this product and observe under a microscope: the diameter of the threaded conduit is 7.5-25 μm, the fibers are bundled, the wall is thicker, and the diameter of the calcium oxalate cube is 7.5-26 μm (Aidi tea).

[0091] The TLC identification of Aodi tea includes the following steps: take 2 tablets of this product, remove the coating, grind finely, add 20ml of methanol, ultrasonically treat for 30 minutes, filter, and concentrate the filtrate to about 2ml as the test solution. Take another appropriate amount of petracenin reference substance, add methanol to make a solution containing 1mg per 1ml, as the reference substance solution. According to the test of thin-layer chromatography (Appendix VI B, Chinese Pharmacopoeia, 2010 Edition), draw 3 μl of the above two solutions, respectivel...

Embodiment 2

[0102] Compound Aodi Tea Tablets (Film Coated Tablets) Batch Number: 20111205

[0103] (1) Identification:

[0104] The microscopic identification of Aodi tea includes the following steps: Take this product and observe under a microscope: the diameter of the threaded conduit is 7.5-25 μm, the fibers are bundled, the wall is thicker, and the diameter of the calcium oxalate cube is 7.5-26 μm (Aidi tea).

[0105] The TLC identification of Aodi tea includes the following steps: take 2 tablets of this product, remove the coating, grind finely, add 20ml of methanol, ultrasonically treat for 30 minutes, filter, and concentrate the filtrate to about 2ml as the test solution. Take another appropriate amount of petracenin reference substance, add methanol to make a solution containing 1mg per 1ml, as the reference substance solution. According to the test of thin-layer chromatography (Appendix VI B, Chinese Pharmacopoeia, 2010 Edition), draw 5 μl of the above two solutions, respectivel...

Embodiment 3

[0116] Compound Awari Tea Tablets (Sugar-coated Tablets) Batch Number: 20111201

[0117] (1) Identification:

[0118] The microscopic identification of Aodi tea includes the following steps: Take this product and observe under a microscope: the diameter of the threaded conduit is 7.5-25 μm, the fibers are bundled, the wall is thicker, and the diameter of the calcium oxalate cube is 7.5-26 μm (Aidi tea).

[0119] The TLC identification of Aodi tea includes the following steps: take 2 tablets of this product, remove the coating, grind finely, add 20ml of methanol, ultrasonically treat for 30 minutes, filter, and concentrate the filtrate to about 2ml as the test solution. Take another appropriate amount of petracenin reference substance, add methanol to make a solution containing 1mg per 1ml, as the reference substance solution. According to the test of thin-layer chromatography (Appendix VI B, Chinese Pharmacopoeia, 2010 Edition), draw 4 μl of the above two solutions, respectiv...

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Abstract

The present invention discloses a qualitative and quantitative detection method of compound Japanese Ardisia Herb tablets, wherein microscopic identification of Japanese Ardisia Herb in the compound Japanese Ardisia Herb tablets is improved, thin-layer chromatography identification of Japanese Ardisia Herb, Dendranthema indicum and licorice root in the compound Japanese Ardisia Herb tablets is added, and a determination method of the bergenin content in the compound Japanese Ardisia Herb tablets is established. According to the qualitative and quantitative detection method, the identification is provided, wherein the microscopic identification method is adopted to identify the Japanese Ardisia Herb, and the thin-layer chromatography method is adopted to identify the Japanese Ardisia Herb, the Dendranthema indicum and the licorice root; the content determination is provided, wherein the high performance liquid chromatography method is adopted to determine the bergenin content in the Japanese Ardisia Herb; and the Japanese Ardisia Herb content in each compound Japanese Ardisia Herb tablet is not less than 1.5 mg (calculated as the bergenin (C14H16O9)). According to the present invention, with the method, the product quality controllability can be increased, and the shortcomings in the prior art can be overcome so as to well ensure the efficacy and provide good service for the majority of patients.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a quality control method for compound ayurvedic tea tablets. Background technique [0002] Compound Aidi Tea Tablets are medicines for clearing away heat and detoxification, reducing phlegm and relieving cough. It is clinically used for cough due to lung heat and chronic bronchitis. Its original quality standard is the standard issued by the ministry, standard number: WS 3 -B-1793-94, there is only 1 microscopic identification and 2 chemical identifications in the original standard, which is difficult to effectively control product quality. China Pharmaceutical Affairs, Volume 24, No. 10, 2010, "HPLC Determination of Petracenin Content in Compound Aidi Tea Tablets" records the method for determining the content of petracenin in Compound Aidi Tea Tablets by HPLC method, China Pharmaceutical Industry 2009 Volume 18, No. 22 "Determination of petra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N30/90
Inventor 辛秀谷陟欣张妮瑜欧金秀郗瑞云袁莉朱丽颜冬兰
Owner JIUZHITANG
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