Application of Activin A in preparation of medicine for treating withdrawal symptoms after mental excitation type drug addiction
A technology for mental excitement and withdrawal symptoms, applied in drug combinations, pharmaceutical formulas, nervous system diseases, etc., can solve problems such as effective treatment, achieve non-toxic side effects, and improve anxiety and depression behaviors
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[0017] 1. Experimental animals
[0018] 7-10 weeks old SPF grade male Kunming mice (body weight 20-25g), all the mice had free access to water and diet, and were maintained in a constant temperature environment of 12h:12h light:dark.
[0019] 2. Experimental Grouping and Drug Treatment
[0020] The mice were randomly divided into four groups, 15 in each group: ①Saline+PBS group; ②Saline+Activin A group; ③Cocaine+PBS group; ④Cocaine+Activin A group. Group ③ and ④ received continuous injection of 20 mg / kg of cocaine (Cocaine). Group ① and ② received continuous injection of the same amount of normal saline (Saline). The four groups received continuous injection for 14 days. Among them, on the 8th day of cocaine injection, indwelling catheters were placed in the bilateral hippocampus of the bilateral mouse brain, and the coordinate points were 2.0 mm posterior to the bregma, left and right diameter ± 1.5 mm, and subdural 1.8 mm. After 14 days of injection and 48 hours after ...
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