Application of Activin A in preparation of medicine for treating withdrawal symptoms after mental excitation type drug addiction

A technology for mental excitement and withdrawal symptoms, applied in drug combinations, pharmaceutical formulas, nervous system diseases, etc., can solve problems such as effective treatment, achieve non-toxic side effects, and improve anxiety and depression behaviors

Inactive Publication Date: 2015-02-18
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Drug addiction is a complex brain disease. At present, there is no drug that can effectively treat the mental changes caused by cocaine addiction and withdrawal

Method used

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  • Application of Activin A in preparation of medicine for treating withdrawal symptoms after mental excitation type drug addiction
  • Application of Activin A in preparation of medicine for treating withdrawal symptoms after mental excitation type drug addiction
  • Application of Activin A in preparation of medicine for treating withdrawal symptoms after mental excitation type drug addiction

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1. Experimental animals

[0018] 7-10 weeks old SPF grade male Kunming mice (body weight 20-25g), all the mice had free access to water and diet, and were maintained in a constant temperature environment of 12h:12h light:dark.

[0019] 2. Experimental Grouping and Drug Treatment

[0020] The mice were randomly divided into four groups, 15 in each group: ①Saline+PBS group; ②Saline+Activin A group; ③Cocaine+PBS group; ④Cocaine+Activin A group. Group ③ and ④ received continuous injection of 20 mg / kg of cocaine (Cocaine). Group ① and ② received continuous injection of the same amount of normal saline (Saline). The four groups received continuous injection for 14 days. Among them, on the 8th day of cocaine injection, indwelling catheters were placed in the bilateral hippocampus of the bilateral mouse brain, and the coordinate points were 2.0 mm posterior to the bregma, left and right diameter ± 1.5 mm, and subdural 1.8 mm. After 14 days of injection and 48 hours after ...

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Abstract

The invention discloses an application of Activin A in preparation of medicine for treating withdrawal symptoms after mental excitation type drug addiction. An open field test and an elevated plus-maze test for researching anxiety behaviors as well as a tail suspension test and a forced swimming test for researching depression behaviors show that Activin A has a therapeutical effect on neurodegeneration diseases and can effectively relieve anxiety and depression behaviors induced by cocaine withdrawal, and further, Activin A almost does not have toxic and side effects on cells, has good development prospect and is expected to be developed into novel medicine for treating the neurodegeneration diseases, particularly the novel medicine for treating withdrawal symptoms after cocaine addiction.

Description

technical field [0001] The invention relates to the application of Activin A in the preparation of a drug for treating withdrawal symptoms after psychostimulant drug addiction. Background technique [0002] Drug addiction is a long-lasting brain disease that is highly prone to relapse even after prolonged withdrawal. The main manifestation is that patients are physically and psychologically dependent on drugs, and this sense of dependence will prompt patients to obtain and use drugs compulsively and recklessly. Long-term drug use can cause dysfunction and pathological changes in the body, resulting in mental disorders such as anxiety and depression. [0003] A large number of data show that repeated exposure to drugs can lead to stable changes in the brain, and participate in the long-term and sustained changes in neural circuits, resulting in long-lasting neural changes, including changes in intracellular signaling pathways, changes in dendrite morphology and behavioral ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61P25/36A61P25/00A61P25/22A61P25/24
Inventor 张璐张琳李娟薛进华
Owner SOUTHERN MEDICAL UNIVERSITY
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